ArticlePloS one2013
Viral etiology and clinical profiles of children with severe acute respiratory infections in China.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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35 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Hospital utilization rates for influenza and RSV: a novel approach and critical assessment.Population health metrics · 2021Pooled it
- The prevalence and role of human respiratory syncytial virus in pediatric respiratory tract infections: a systematic review and meta-analysis of global data.EClinicalMedicine · 2026Article
- Analysis of common respiratory pathogens in children aged 0-5 years with community-acquired pneumonia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Molecular detection and genotyping of HMPV in patients with severe acute respiratory infection in India.Annals of medicine · 2024Article
- Characterization of viral infections in children with influenza-like-illness during December 2018-January 2019.Frontiers in cellular and infection microbiology · 2023Article
- Molecular investigation of human metapneumovirus in children with acute respiratory infections in Chennai, South India, from 2016-2018.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Causes of Lower Respiratory Tract Infections and the Use of Diagnostic Biomarkers in Blood Samples from Children in Hohhot, Inner Mongolia, China, Between July 2019 and June 2020.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Viral etiology and epidemiology of pediatric patients hospitalized for acute respiratory tract infections in Macao: a retrospective study from 2014 to 2017.BMC infectious diseases · 2021Article
- Seroprevalence of SARS-CoV-2 infections among children visiting a hospital.Pediatric investigation · 2020Article
- Epidemiology and Genetic Variability of Circulating Influenza B Viruses in Uruguay, 2012-2019.Microorganisms · 2020Article
- Outbreak of Human Metapneumovirus in a Nursing Home: A Clinical Perspective.Journal of the American Medical Directors Association · 2020Article
- Comparison of viral and epidemiological profiles of hospitalized children with severe acute respiratory infection in Beijing and Shanghai, China.BMC infectious diseases · 2019Article
- Viral prevalence, clinical profiles and comparison of severity scores for predicting the mortality of adults with severe acute respiratory infectionsTurkish journal of medical sciences · 2019Observational
- Clinical characteristics and outcomes of patients with severe acute respiratory infections (SARI): results from the Egyptian surveillance study 2010-2014.Multidisciplinary respiratory medicine · 2019Article
- Epidemiology and clinical characteristics of acute respiratory tract infections among hospitalized infants and young children in Chengdu, West China, 2009-2014.BMC pediatrics · 2018Article
- Genotypic Diversity and Epidemiology of Human Rhinovirus Among Children With Severe Acute Respiratory Tract Infection in Shanghai, 2013-2015.Frontiers in microbiology · 2018Article
- Comparison of Influenza Epidemiological and Virological Characteristics between Outpatients and Inpatients in Zhejiang Province, China, March 2011-June 2015.International journal of environmental research and public health · 2017Article
- Article
- Epidemiology and clinical profile of pathogens responsible for the hospitalization of children in Sousse area, Tunisia.PloS one · 2017Article
- Infections and coinfections by respiratory human bocavirus during eight seasons in hospitalized children.Journal of medical virology · 2016Article
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8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNo comprehensive analysis is available on the viral etiology and clinical characterization among children with severe acute respiratory infection (SARI) in China during 2009 H1N1 pandemic and post-pandemic period.
methodsCohort of 370 hospitalized children (1 to 72 months) with SARI from May 2008 to March 2010 was enrolled in this study. Nasopharyngeal aspirate (NPA) specimens were tested by a commercial assay for 18 respiratory viral targets. The viral distribution and its association with clinical character were statistically analyzed.
resultsViral pathogen was detected in 350 (94.29%) of children with SARI. Overall, the most popular viruses were: enterovirus/rhinovirus (EV/RV) (54.05%), respiratory syncytial virus (RSV) (51.08%), human bocavirus (BoCA) (33.78%), human parainfluenzaviruse type 3 (PIV3) (15.41%), and adenovirus (ADV) (12.97%). Pandemic H1N1 was the dominant influenza virus (IFV) but was only detected in 20 (5.41%) of children. Moreover, detection rate of RSV and human metapneumovirus (hMPV) among suburb participants were significantly higher than that of urban area (P<0.05). Incidence of VSARI among suburb participants was also significant higher, especially among those of 24 to 59 months group (P<0.05).
conclusionPiconaviruses (EV/RV) and paramyxoviruses are the most popular viral pathogens among children with SARI in this study. RSV and hMPV significantly increase the risk of SARI, especially in children younger than 24 months. Higher incidence of VSARI and more susceptibilities to RSV and hMPV infections were found in suburban patients.
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