ArticlePloS one2013
Acute physiological stress down-regulates mRNA expressions of growth-related genes in coho salmon.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 68 citations in OpenAlex.
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- Effects of dietary Lactococcus lactis supplementation on growth performance, intestinal and water microbiota of juvenile American Shad (Alosa sapidissima) under high temperature.World journal of microbiology & biotechnology · 2025Article
- Extended Photoperiod Facilitated the Restoration of the Expression of GH-IGF Axis Genes in Submerged Rainbow Trout (International journal of molecular sciences · 2024Article
- Understanding the molecular mechanism of arsenic and ammonia toxicity and high-temperature stress in Pangasianodon hypophthalmus.Environmental science and pollution research international · 2024Article
- Multifunctional role of dietary copper to regulate stress-responsive gene for mitigation of multiple stresses in Pangasianodon hypophthalmus.Scientific reports · 2024Article
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- Nano-copper Enhances Gene Regulation of Non-specific Immunity and Antioxidative Status of Fish Reared Under Multiple Stresses.Biological trace element research · 2023Article
- Age-Dependent Effects of Chronic Stress on Zebrafish Behavior and Regeneration.Frontiers in physiology · 2022Article
- Understanding acute stress-mediated immunity in teleost fish.Fish and shellfish immunology reports · 2021Review
- Properties of Carotenoids in Fish Fitness: A Review.Marine drugs · 2020Review
- Effects of crowding on the three main proteolytic mechanisms of skeletal muscle in rainbow trout (Oncorhynchus mykiss).BMC veterinary research · 2020Article
- Identification and Evaluation of Long Noncoding RNAs in Response to Handling Stress in Red Cusk-Eel (Genypterus chilensis) via RNA-seq.Marine biotechnology (New York, N.Y.) · 2020Article
- Diet Supplemented With Synthetic Carotenoids: Effects on Growth Performance and Biochemical and Immunological Parameters of Yellow Perch (Frontiers in physiology · 2019Article
- Effect of excessive doses of oxytetracycline on stress-related biomarker expression in coho salmon.Environmental science and pollution research international · 2018Article
- Article
- Acute stress is detrimental to heart regeneration in zebrafish.Open biology · 2016Article
- Effect of acute ammonia exposure on expression of GH/IGF axis genes GHR1, GHR2 and IGF-1 in pufferfish (Takifugu obscurus).Fish physiology and biochemistry · 2015Article
- Effect of severe environmental thermal stress on redox state in salmon.Redox biology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth and development in fish are regulated to a major extent by growth-related factors, such as liver-derived insulin-like growth factor (IGF) -1 in response to pituitary-secreted growth hormone (GH) binding to the GH receptor (GHR). Here, we report on the changes in the expressions of gh, ghr, and igf1 genes and the circulating levels of GH and IGF-1 proteins in juvenile coho salmon (Oncorhynchus kisutch) in response to handling as an acute physiological stressor. Plasma GH levels were not significantly different between stressed fish and prestressed control. Plasma IGF-1 concentrations in stressed fish 1.5 h post-stress were the same as in control fish, but levels in stressed fish decreased significantly 16 h post-stress. Real-time quantitative PCR (qPCR) analysis showed that ghr mRNA levels in pituitary, liver, and muscle decreased gradually in response to the stressor. After exposure to stress, hepatic igf1 expression transiently increased, whereas levels decreased 16 h post-stress. On the other hand, the pituitary gh mRNA level did not change in response to the stressor. These observations indicate that expression of gh, ghr, and igf1 responded differently to stress. Our results show that acute physiological stress can mainly down-regulate the expressions of growth-related genes in coho salmon in vivo. This study also suggests that a relationship between the neuroendocrine stress response and growth-related factors exists in fish.
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