SynthesisPloS one2013
Relationship between periodontitis and pre-eclampsia: a meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Periodontitis and Preeclampsia in Pregnancy: A Systematic Review and Meta-Analysis.Maternal and child health journal · 2022Pooled it
- SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis.American journal of obstetrics and gynecology · 2022Pooled it
- Vitamin D and Calcium Milk Fortification in Pregnant Women with Periodontitis: A Feasibility Trial.International journal of environmental research and public health · 2020Trial
- Comparative evaluation of knowledge levels and attitudes regarding periodontal health and periodontal disease among internal medicine physicians and dentists in Turkey: a cross-sectional survey study.BMC medical education · 2026Article
- Trophoblast cell response to periodontal pathogens unveils oxidative stress networks between periodontitis and pre-eclampsia: Mendelian randomization, transcriptomic analysis, and cellular experimental validation.European journal of medical research · 2025Article
- Relationship between periodontitis and systemic health conditions: a narrative review.Ewha medical journal · 2025Review
- Evaluation the Risk of Preeclampsia in Periodontal Patients Compared With Healthy Individuals: A Meta-Analysis Study.International journal of dentistry · 2025Article
- The relationships of inflammatory blood markers with maternal periodontal and dental states and their effects on preterm membrane rupture development.BMC oral health · 2024Article
- Knowledge and Practice Behaviours of Obstetricians/Gynecologists and Midwives Concerning Periodontal Health and Pregnancy.Oral health & preventive dentistry · 2023Article
- Adverse Pregnancy Outcomes and Maternal Periodontal Disease: An Overview on Meta-Analytic and Methodological Quality.Journal of clinical medicine · 2023Review
- Review
- Periodontal Diseases and Pregnancy: Knowledge and Clinical Practice Habits of French Midwives.Oral health & preventive dentistry · 2022Article
- Periodontal Conditions and Pathogens Associated with Pre-Eclampsia: A Scoping Review.International journal of environmental research and public health · 2021Article
- Periodontitis, Blood Pressure, and the Risk and Control of Arterial Hypertension: Epidemiological, Clinical, and Pathophysiological Aspects-Review of the Literature and Clinical Trials.Current hypertension reports · 2021Review
- Pregnancy and Dentistry: A Literature Review on Risk Management during Dental Surgical Procedures.Dentistry journal · 2021Review
- Radiological screening of maternal periodontitis for predicting adverse pregnancy and neonatal outcomes.Scientific reports · 2020Article
- Validation and development of models using clinical, biochemical and ultrasound markers for predicting pre-eclampsia: an individual participant data meta-analysis.Health technology assessment (Winchester, England) · 2020Article
- "Got to build that trust": the perspectives and experiences of Aboriginal health staff on maternal oral health.International journal for equity in health · 2020Article
- Gestational diabetes and the human salivary microbiota: a longitudinal study during pregnancy and postpartum.BMC pregnancy and childbirth · 2020Observational
- Gynecologists' Knowledge of the Association Between Periodontal Health and Female Sex Hormones.Cureus · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies have suggested controversial results regarding a possible association between pre-eclampsia (PE) and periodontal disease (PD) and no meta-analysis has been performed to clarify this issue.
methodsA literature search of electronic databases was performed for articles published through March 24, 2013, followed by a manual search of several dental and medical journals. The meta-analysis was conducted according to the recommendations of the Cochrane Collaboration and PRISMA. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed with the χ(2)-based Cochran Q test and I(2) statistic. The level of significance was set at P <0.05.
resultsFifteen studies were included, including three cohort and 12 case-control studies. A positive association was found between PE and PD (OR 2.17, 95% CI 1.38-3.41, P = 0.0008). However, a high and significant heterogeneity was found (χ(2) = 62.42, P<0.00001, I(2) = 75%). In most cases, subgroup analysis had low power to detect significant differences between PE and non-PE groups.
conclusionBased on the findings of the meta-analysis, PD appears to be a possible risk factor for PE. However, given the important differences in the definitions and diagnoses of PD and PE among the studies, as well as their lack of good methodological quality, future trials are needed to confirm the results of the present meta-analysis.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.