SynthesisPloS one2013
Association between CD14 promoter -159C/T polymorphism and the risk of sepsis and mortality: a systematic review and meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Genetic association studies in critically ill patients: a systematic review.EBioMedicine · 2025Pooled it
- Association between innate immunity gene polymorphisms and neonatal sepsis development: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2022Pooled it
- Association between the -159C/T polymorphism in the promoter region of the CD14 gene and sepsis: a meta-analysis.BMC anesthesiology · 2017Pooled it
- Pooled it
- [Recent research on gene polymorphisms and genetic susceptibility of neonatal sepsis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- Quality Control Measures and Validation in Gene Association Studies: Lessons for Acute Illness.Shock (Augusta, Ga.) · 2020Review
- Association of Gene Polymorphism ofOpen access Macedonian journal of medical sciences · 2019Article
- Multiplexed Electrochemical Cancer Diagnostics With Automated Microfluidics.Electroanalysis · 2019Article
- Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study.Scientific reports · 2018Article
- Interaction of CD14 haplotypes and soluble CD14 on pulmonary function in agricultural workers.Respiratory research · 2017Article
- The Relevance of Coding Gene Polymorphysms of Cytokines and Cellular Receptors in Sepsis.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2017Review
- The role of genetics and antibodies in sepsis.Annals of translational medicine · 2016Review
- Relationship between CD14-159C/T gene polymorphism and acute brucellosis risk.Asian Pacific journal of tropical medicine · 2016Article
- Association between Toll-Like Receptor 4 and Occurrence of Type 2 Diabetes Mellitus Susceptible to Pulmonary Tuberculosis in Northeast China.Stem cells international · 2016Article
- Association of susceptibility to septic shock with platelet endothelial cell adhesion molecule-1 gene Leu125Val polymorphism and serum sPECAM-1 levels in sepsis patients.International journal of clinical and experimental medicine · 2015Article
- Observational
- The association of polymorphisms of TLR4 and CD14 genes with susceptibility to sepsis in a Chinese population.BMC medical genetics · 2014Article
- Genetic polymorphisms and sepsis in premature neonates.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies on the association between CD14-159C/T polymorphism and sepsis showed inconclusive results. Accordingly, we conducted a comprehensive literature search and a meta-analysis to determine whether the CD14-159C/T polymorphism conferred susceptibility to sepsis or was associated with increased risk of death from sepsis. METHODOLOGY: Data were collected from the following electronic databases: PubMed, Embase, Medline, Web of Knowledge, and HuGE Navigator, with the last report up to June 15, 2012. The odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of association. We summarized the data on the association between CD14-159C/T polymorphism and sepsis in the overall population and subgroup by ethnicity and sepsis subtype. PRINCIPAL
findingsA total of 16 studies on sepsis morbidity (1369 cases and 2382 controls) and 4 studies on sepsis mortality (731 sepsis patients) met the inclusion criteria for meta-analysis. Overall analysis showed no strong evidences of association with sepsis susceptibility under any genetic model. However, slight associations were found in Asian populations (dominant model: OR = 1.38, 95%CI = 0.96-1.98, P = 0.08) and septic shock patients (dominant model: OR = 1.72, 95%CI 1.05-2.83, P = 0.03; allelic model: OR = 1.52, 95%CI 1.09-2.12, P = 0.01) in the stratified analysis. Moreover, there was borderline association between CD14-159C/T and sepsis mortality under the dominant genetic model (OR = 1.44, 95%CI = 0.98-2.11, P = 0.06). CONCLUSIONS/SIGNIFICANCE: This meta-analysis suggests that the CD14-159C/T polymorphism may not be a significant susceptibility factor in the risk of sepsis and mortality. Only weak associations were observed in Asian populations and septic shock patients. More studies based on larger sample sizes and homogeneous sepsis patients are needed to confirm these findings.
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