ArticlePloS one2013
Urinary uromodulin excretion predicts progression of chronic kidney disease resulting from IgA nephropathy.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Serum uromodulin is associated with the severity of clinicopathological findings in ANCA-associated glomerulonephritis.PloS one · 2019Trial
- Urinary Uromodulin for Distinguishing Between Glomerulonephritis, Diabetic Kidney Disease, and Nephrosclerosis in a Biopsy-Proven Cohort.Diagnostics (Basel, Switzerland) · 2026Article
- Recent advances in the clinical significance and physiological functions of uromodulin: a narrative review.BMC nephrology · 2026Review
- Uromodulin and progression of IgA nephropathy.Clinical kidney journal · 2024Article
- Unveiling the Hidden Power of Uromodulin: A Promising Potential Biomarker for Kidney Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Combined Use of Serum Uromodulin and eGFR to Estimate Mortality Risk.Frontiers in medicine · 2021Article
- Article
- Urinary Uromodulin Levels andInternational journal of nephrology · 2019Article
- Loquat leaf polysaccharides improve glomerular injury in rats with anti-Thy 1 nephritis via peroxisome proliferator-activated receptor alpha pathway.American journal of translational research · 2019Article
- Effect of UMOD genotype on long-term graft survival after kidney transplantation in patients treated with cyclosporine-based therapy.The pharmacogenomics journal · 2018Article
- Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy.Physiological reports · 2018Article
- Serum uromodulin-a marker of kidney function and renal parenchymal integrity.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Article
- Serum Uromodulin: A Biomarker of Long-Term Kidney Allograft Failure.American journal of nephrology · 2018Article
- Hypothesis: Potential Utility of Serum and Urine Uromodulin Measurement in Kidney Transplant Recipients?Transplantation direct · 2017Review
- Novel Biomarkers in the Diagnosis of Chronic Kidney Disease and the Prediction of Its Outcome.International journal of molecular sciences · 2017Review
- Association of urinary uromodulin with kidney function decline and mortality: the health ABC study .Clinical nephrology · 2017Article
- Interaction of uromodulin and complement factor H enhances C3b inactivation.Journal of cellular and molecular medicine · 2016Article
- Urinary uromodulin, kidney function, and cardiovascular disease in elderly adults.Kidney international · 2015Article
- Urinary biomarkers at early ADPKD disease stage.PloS one · 2015Article
- Validation of potential candidate biomarkers of drug-induced nephrotoxicity and allodynia in medication-overuse headache.The journal of headache and pain · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUromodulin, or Tamm-Horsfall protein, is the most abundant urinary protein in healthy individuals. Recent studies have suggested that uromodulin may play a role in chronic kidney diseases. We examined an IgA nephropathy cohort to determine whether uromodulin plays a role in the progression of IgA nephropathy.
methodsA total of 344 IgA nephropathy patients were involved in this study. Morphological changes were evaluated with the Oxford classification of IgA nephropathy. Enzyme Linked Immunosorbent Assay (ELISA) measured the urinary uromodulin level on the renal biopsy day. Follow up was done regularly on 185 patients. Time-average blood pressure, time-average proteinuria, estimated glomerular filtration rate (eGFR) and eGFR decline rate were caculated. Association between the urinary uromodulin level and the eGFR decline rate was analyzed with SPSS 13.0.
resultsWe found that lower baseline urinary uromodulin levels (P = 0.03) and higher time-average proteinuria (P = 0.04) were risk factors for rapid eGFR decline in a follow-up subgroup of the IgA nephropathy cohort. Urinary uromodulin level was correlated with tubulointerstitial lesions (P = 0.016). Patients that had more tubular atrophy/interstitial fibrosis on the surface had lower urinary uromodulin levels (P = 0.02).
conclusionsUrinary uromodulin level is associated with interstitial fibrosis/tubular atrophy and contributes to eGFR decline in IgA nephropathy.
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