Trial reportPloS one2013
Early PTSD symptom trajectories: persistence, recovery, and response to treatment: results from the Jerusalem Trauma Outreach and Prevention Study (J-TOPS).
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 79 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 8 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Early pharmacological interventions for prevention of post-traumatic stress disorder (PTSD) in individuals experiencing acute traumatic stress symptoms.The Cochrane database of systematic reviews · 2024Pooled it
- Effect of sleep manipulations on intrusive memories after exposure to an experimental analogue trauma: A meta-analytic review.Sleep medicine reviews · 2023Pooled it
- Early pharmacological interventions for universal prevention of post-traumatic stress disorder (PTSD).The Cochrane database of systematic reviews · 2022Pooled it
- Change in prevalence of post-traumatic stress disorder in the two years following trauma: a meta-analytic study.European journal of psychotraumatology · 2022Pooled it
- Role of social cognition in post-traumatic stress disorder: A review and meta-analysis.Genes, brain, and behavior · 2019Pooled it
- Can't get it out of my mind: A systematic review of predictors of intrusive memories of distressing events.Psychological bulletin · 2018Pooled it
- Cortisol, heart rate, and blood pressure as early markers of PTSD risk: A systematic review and meta-analysis.Clinical psychology review · 2016Pooled it
- Pharmacological interventions for preventing post-traumatic stress disorder (PTSD).The Cochrane database of systematic reviews · 2014Pooled it
- Open Trial of a Brief Imagery-Based Stabilization Psychotherapy for Adults with Acute Posttraumatic Stress Disorder.Yonsei medical journal · 2024Trial
- A guided single session intervention to reduce intrusive memories of work-related trauma: a randomised controlled trial with healthcare workers in the COVID-19 pandemic.BMC medicine · 2024Trial
- Longitudinal Trajectories of Alcohol Use in Vietnamese Adults with Hazardous Alcohol Use and HIV.AIDS and behavior · 2023Trial
- Technology-Enhanced Stepped Collaborative Care Targeting Posttraumatic Stress Disorder and Comorbidity After Injury: A Randomized Controlled Trial.Journal of traumatic stress · 2015Trial
- Circadian instability following mass trauma predicts PTSD risk.Translational psychiatry · 2026Article
- Growth Trajectories of Medication Adherence in Pediatric Organ Transplantation and Their Relationship to Posttransplant Health Outcomes.Transplantation direct · 2026Article
- Predicting PTSD development with early post-trauma assessments: a proof-of-concept for a concise tree-based classification method.European journal of psychotraumatology · 2025Article
- The hunt for the last relevant paper: blending the best of humans and AI.European journal of psychotraumatology · 2025Article
- Sequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Association of pre- and postinjury mental health with long-term clinical and financial outcomes.The journal of trauma and acute care surgery · 2025Article
- Sex Differences in Response Inhibition-Related Neural Predictors of Posttraumatic Stress Disorder in Civilians With Recent Trauma.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Defining theNature. Mental health · 2024Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextUncovering heterogeneities in the progression of early PTSD symptoms can improve our understanding of the disorder's pathogenesis and prophylaxis.
objectivesTo describe discrete symptom trajectories and examine their relevance for preventive interventions.
designLatent Growth Mixture Modeling (LGMM) of data from a randomized controlled study of early treatment. LGMM identifies latent longitudinal trajectories by exploring discrete mixture distributions underlying observable data.
settingHadassah Hospital unselectively receives trauma survivors from Jerusalem and vicinity.
participantsAdult survivors of potentially traumatic events consecutively admitted to the hospital's emergency department (ED) were assessed ten days and one-, five-, nine- and fifteen months after ED admission. Participants with data at ten days and at least two additional assessments (n = 957) were included; 125 received cognitive behavioral therapy (CBT) between one and nine months. APPROACH: We used LGMM to identify latent parameters of symptom progression and tested the effect of CBT on these parameters. CBT consisted of 12 weekly sessions of either cognitive therapy (n = 41) or prolonged exposure (PE, n = 49), starting 29.8±5.7 days after ED admission, or delayed PE (n = 35) starting at 151.8±42.4 days. CBT effectively reduced PTSD symptoms in the entire sample.
main outcome measureLatent trajectories of PTSD symptoms; effects of CBT on these trajectories.
resultsTHREE TRAJECTORIES WERE IDENTIFIED: Rapid Remitting (rapid decrease in symptoms from 1- to 5-months; 56% of the sample), Slow Remitting (progressive decrease in symptoms over 15 months; 27%) and Non-Remitting (persistently elevated symptoms; 17%). CBT accelerated the recovery of the Slow Remitting class but did not affect the other classes.
conclusionsThe early course of PTSD symptoms is characterized by distinct and diverging response patterns that are centrally relevant to understanding the disorder and preventing its occurrence. Studies of the pathogenesis of PTSD may benefit from using clustered symptom trajectories as their dependent variables.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.