ArticlePLoS computational biology2013
Causes and consequences of hyperexcitation in central clock neurons.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Interpretable machine learning reveals hemispheric asymmetry of state switching in the suprachiasmatic nucleus.Patterns (New York, N.Y.) · 2026Article
- Plasticity manifolds and degeneracy govern circadian oscillations of neuronal intrinsic properties in the suprachiasmatic nucleus.iScience · 2023Article
- Aging affects GABAergic function and calcium homeostasis in the mammalian central clock.Frontiers in neuroscience · 2023Article
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- Bright daytime light enhances circadian amplitude in a diurnal mammal.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Targeted modification of the Per2 clock gene alters circadian function in mPer2luciferase (mPer2Luc) mice.PLoS computational biology · 2021Article
- M1-Type, but Not M4-Type, Melanopsin Ganglion Cells Are Physiologically Tuned to the Central Circadian Clock.Frontiers in neuroscience · 2021Article
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- Novel description of the large conductance CaPhysiological reports · 2017Article
- Delayed Cryptochrome Degradation Asymmetrically Alters the Daily Rhythm in Suprachiasmatic Clock Neuron Excitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The shaping of intrinsic membrane potential oscillations: positive/negative feedback, ionic resonance/amplification, nonlinearities and time scales.Journal of computational neuroscience · 2017Article
- Synchronous circadian voltage rhythms with asynchronous calcium rhythms in the suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Circadian regulation of mouse suprachiasmatic nuclei neuronal states shapes responses to orexin.The European journal of neuroscience · 2017Article
- Computational modeling of the cell-autonomous mammalian circadian oscillator.BMC systems biology · 2017Article
- Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability.Nature communications · 2016Article
- The Neurobiology of Circadian Rhythms.The Psychiatric clinics of North America · 2015Review
- Article
- Distinct roles for GABA across multiple timescales in mammalian circadian timekeeping.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Hyperexcited states, including depolarization block and depolarized low amplitude membrane oscillations (DLAMOs), have been observed in neurons of the suprachiasmatic nuclei (SCN), the site of the central mammalian circadian (~24-hour) clock. The causes and consequences of this hyperexcitation have not yet been determined. Here, we explore how individual ionic currents contribute to these hyperexcited states, and how hyperexcitation can then influence molecular circadian timekeeping within SCN neurons. We developed a mathematical model of the electrical activity of SCN neurons, and experimentally verified its prediction that DLAMOs depend on post-synaptic L-type calcium current. The model predicts that hyperexcited states cause high intracellular calcium concentrations, which could trigger transcription of clock genes. The model also predicts that circadian control of certain ionic currents can induce hyperexcited states. Putting it all together into an integrative model, we show how membrane potential and calcium concentration provide a fast feedback that can enhance rhythmicity of the intracellular circadian clock. This work puts forward a novel role for electrical activity in circadian timekeeping, and suggests that hyperexcited states provide a general mechanism for linking membrane electrical dynamics to transcription activation in the nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.