ArticleBlood2013
Ikaros limits basophil development by suppressing C/EBP-α expression.
Article in Blood, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia.Haematologica · 2015Trial
- Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation.Immunological reviews · 2025Review
- Novel insights into the ontogeny of basophils.Frontiers in allergy · 2024Review
- The ontogenesis and heterogeneity of basophils.Discovery immunology · 2024Review
- Article
- IKAROS in Acute Leukemia: A Positive Influencer or a Mean Hater?International journal of molecular sciences · 2023Review
- Article
- Immature tertiary lymphoid structure formation was increased in the melanoma tumor microenvironment ofTranslational cancer research · 2022Article
- IKAROS-Associated Diseases in 2020: Genotypes, Phenotypes, and Outcomes in Primary Immune Deficiency/Inborn Errors of Immunity.Journal of clinical immunology · 2021Review
- Ikzf1 regulates embryonic T lymphopoiesis via Ccr9 and Irf4 in zebrafish.The Journal of biological chemistry · 2019Article
- Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency.The Journal of clinical investigation · 2018Article
- The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia.Haematologica · 2018Review
- Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos.Human molecular genetics · 2017Article
- Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Normal hematologic parameters and fetal hemoglobin silencing with heterozygous IKZF1 mutations.Blood · 2016Article
- Transcriptional regulation of mast cell and basophil lineage commitment.Seminars in immunopathology · 2016Review
- The Evolution of Human Basophil Biology from Neglect towards Understanding of Their Immune Functions.BioMed research international · 2016Review
- Transcription Factor Repertoire of Homeostatic Eosinophilopoiesis.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression.Blood · 2015Article
- Mechanisms controlling mast cell and basophil lineage decisions.Current allergy and asthma reports · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The Ikaros gene (Ikzf1) encodes a family of zinc-finger transcription factors implicated in hematopoietic cell differentiation. Here we show that Ikaros suppresses the development of basophils, which are proinflammatory cells of the myeloid lineage. In the absence of extrinsic basophil-inducing signals, Ikaros(-/-) (Ik(-/-)) mice exhibit increases in basophil numbers in blood and bone marrow and in their direct precursors in bone marrow and the spleen, as well as decreased numbers of intestinal mast cells. In vitro culture of Ik(-/-) bone marrow under mast cell differentiation conditions also results in predominance of basophils. Basophil expansion is associated with an increase in basophil progenitors, increased expression of Cebpa and decreased expression of mast cell-specifying genes Hes1 and microphthalmia-associated transcription factor (Mitf). Ikaros directly associates with regulatory sites within Cebpa and Hes1 and regulates the acquisition of permissive H3K4 tri-methylation marks at the Cebpa locus and reduces H3K4 tri-methylation at the Hes1 promoter. Ikaros blockade in cultured cells or transfer of Ik(-/-) bone marrow into irradiated Ik(+/+) recipients also results in increased basophils confirming a cell-intrinsic effect of Ikaros on basophil development. We conclude that Ikaros is a suppressor of basophil differentiation under steady-state conditions and that it acts by regulating permissive chromatin modifications of Cebpa.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.