Trial reportThe Journal of infectious diseases2014
Effect of early antiretroviral therapy on sexual behaviors and HIV-1 transmission risk among adults with diverse heterosexual partnership statuses in Côte d'Ivoire.
Trial report in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Impact of early antiretroviral treatment on sexual behaviour: a randomised comparison.AIDS (London, England) · 2019Trial
- HIV Transmission Risk Behavior in a Cohort of HIV-Infected Treatment-Naïve Men and Women in the United States.AIDS and behavior · 2016Trial
- Decrease in sexual risk behaviours after early initiation of antiretroviral therapy: a 24-month prospective study in Côte d'Ivoire.Journal of the International AIDS Society · 2014Trial
- Is There Risk Compensation among HIV Infected Youth and Adults 15 Years and Older on Antiretroviral Treatment in South Africa? Findings from the 2017 National HIV Prevalence, Incidence, Behaviour and Communication Survey.International journal of environmental research and public health · 2022Article
- Article
- Risky Sexual Practice, Sexually Transmitted Infection and Associated Factors Among Newly Diagnosed HIV-positive People in Northwest Ethiopia.HIV/AIDS (Auckland, N.Z.) · 2020Article
- No effect of test and treat on sexual behaviours at population level in rural South Africa.AIDS (London, England) · 2019Article
- Impact of early antiretroviral therapy eligibility on HIV acquisition: household-level evidence from rural South Africa.AIDS (London, England) · 2018Article
- Antiretroviral therapy interruptions: impact on HIV treatment and transmission.HIV/AIDS (Auckland, N.Z.) · 2018Review
- Does antiretroviral therapy change partnership dynamics and HIV risk behaviours among HIV-infected adults.AIDS (London, England) · 2017Article
- Article
- Prevention of Sexually Transmitted Diseases in HIV-Infected Individuals.Current HIV/AIDS reports · 2017Review
- Recent Insights into the HIV/AIDS Pandemic.Microbial cell (Graz, Austria) · 2016Review
- HIV Transmission Risk Persists During the First 6 Months of Antiretroviral Therapy.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Addressing social issues in a universal HIV test and treat intervention trial (ANRS 12249 TasP) in South Africa: methods for appraisal.BMC public health · 2015Article
- Observational
- Advances in HIV prevention for serodiscordant couples.Current HIV/AIDS reports · 2014Review
- Risk factors for delayed entrance into care after diagnosis among patients with late-stage HIV disease in southern Vietnam.PloS one · 2014Article
- Health benefits, costs, and cost-effectiveness of earlier eligibility for adult antiretroviral therapy and expanded treatment coverage: a combined analysis of 12 mathematical models.The Lancet. Global health · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of early initiation of antiretroviral therapy (ART; ie, at CD4(+) T-cell counts >350 cells/mm(3)) on sexual behaviors and human immunodeficiency virus type 1 (HIV) transmission risk has not been documented in populations other than HIV-serodiscordant couples in stable relationships.
methodsOn the basis of data from a behavioral study nested in a randomized, controlled trial (Temprano-ANRS12136) of early ART, we compared proportions of risky sex (ie, unprotected sex with a partner of negative/unknown HIV status) reported 12 months after inclusion between participants randomly assigned to initiate ART immediately (hereafter, "early ART") or according to ongoing World Health Organization criteria. Group-specific HIV transmission rates were estimated on the basis of sexual behaviors and viral load-specific per-act HIV transmission probabilities. The ratio of transmission rates was computed to estimate the protective effect of early ART.
resultsAmong 957 participants (baseline median CD4(+) T-cell count, 478 cells/mm(3)), 46.0% reported sexual activity in the past month; of these 46.0%, sexual activity for 41.5% involved noncohabiting partners. The proportion of subjects who engaged in risky sex was 10.0% in the early ART group, compared with 12.8% in the standard ART group (P = .17). After accounting for sexual behaviors and viral load, we estimated that the protective effect of early ART was 90% (95% confidence interval, 81%-95%).
conclusionTwelve months after inclusion, patients in the early and standard ART groups reported similar sexual behaviors. Early ART decreased the estimated risk of HIV transmission by 90%, suggesting a major prevention benefit among seronegative sex partners in stable or casual relationships with seropositive individuals.
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