Observational studyInternational urology and nephrology2014
Procalcitonin: diagnostic value in systemic infections in chronic kidney disease or renal transplant patients.
Observational study in International urology and nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Diagnostic value of procalcitonin for bacterial infections in patients undergoing hemodialysis: a systematic review and meta-analysis.Renal failure · 2022Pooled it
- Can procalcitonin be used to distinguish between disease flare and infection in patients with systemic lupus erythematosus: a systematic literature review.Clinical rheumatology · 2014Pooled it
- Efficacy of vedolizumab as maintenance therapy in a patient with ulcerative colitis on hemodialysis for end-stage renal failure: a case report.Frontiers in medicine · 2025Article
- Acute kidney injury in critical care: complications of hemophagocytic lymphohistiocytosis.Frontiers in immunology · 2024Review
- Early identification of bloodstream infection in hemodialysis patients by machine learning.Heliyon · 2023Article
- Diagnostic and Prognostic Roles of Procalcitonin and Other Tools in Community-Acquired Pneumonia: A Narrative Review.Diagnostics (Basel, Switzerland) · 2023Review
- A retrospective cohort study of the effect of rapid versus delayed-result procalcitonin testing on antibiotic use at a community hospital.International journal of clinical pharmacy · 2022Article
- Procalcitonin in hemodialysis patients presenting with fever or chills to the emergency department.Internal and emergency medicine · 2020Article
- Predictive value of procalcitonin in chronic allograft dysfunction in kidney transplant recipients.Experimental and therapeutic medicine · 2019Article
- Biomarkers and risk factors for sepsis in stage 5 chronic kidney disease: a retrospective case-control study.International urology and nephrology · 2019Article
- Biological variation of procalcitonin levels in hemodialysis patients.Clinical and experimental nephrology · 2019Article
- Predictive value of procalcitonin for diagnosis of infections in patients with chronic kidney disease: a comparison with traditional inflammatory markers C-reactive protein, white blood cell count, and neutrophil percentage.International urology and nephrology · 2017Article
- Usefulness of serum procalcitonin as a diagnostic biomarker of infection in children with chronic kidney disease.Archives of medical sciences. Atherosclerotic diseases · 2016Article
- Circulating bacterial-derived DNA fragment level is a strong predictor of cardiovascular disease in peritoneal dialysis patients.PloS one · 2015Article
- Clinical relevance of procalcitonin and C-reactive protein as infection markers in renal impairment: a cross-sectional study.Critical care (London, England) · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough procalcitonin (PCT) has been described as a marker of infection and inflammation, it has not been extensively studied in patients with chronic kidney disease (CKD), end stage renal disease, or renal transplant.
methodsPCT was routinely tested in 82 (56 dialyzed patients and 28 renal transplant recipients) consecutive cases with a strong clinical suspicion of infection, during a 6-month period, in a single referral unit.
resultsDuring the study period, 58/82 cases had confirmed infections as per definition. Patients with confirmed infections had higher values for PCT [median = 2.5 ng/mL, interquartile range (IR) = 0.9-5 ng/mL] than those without (median = 0.3 ng/mL, IR = 0.1-0.5 ng/mL), p < 0.001. Overall, for a cutoff value of 0.5 ng/mL, the sensitivity of the test was 93.1 % and the specificity 78.6.
conclusionOur data indicate that significantly elevated PCT concentrations offer good sensitivity and specificity for the early diagnosis of systemic bacterial infection in patients with CKD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.