ReviewCurrent rheumatology reports2013
Polymorphism of HLA-B27: 105 subtypes currently known.
Review in Current rheumatology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Significance of HLA in Graves' disease and Graves' orbitopathy in Asian and Caucasian populations - a systematic review.Frontiers in immunology · 2023Pooled it
- SPAID: a comprehensive database for disease-specific autoantigens in autoimmune disorders.Advanced biotechnology · 2026Article
- Mechanistic Insights from Human Studies in Axial Spondyloarthritis: A T Cell Story.Current rheumatology reports · 2026Review
- Metabolomics: A Viable Approach to Understand the Pathogenesis of Reactive ArthritisEndocrine, metabolic & immune disorders drug targets · 2026Review
- CD28 and CTLA4 polymorphisms associated with ankylosing spondylitis: a study in the context of HLA-B27.BMC immunology · 2025Article
- Proteomic Profiling of Inflammatory Protein Dysregulation in HLA-B27-Positive Ankylosing Spondylitis: Molecular Signatures and Potential Biomarkers.Biomolecules · 2025Article
- [The role of HLA-B27 in the pathogenesis and diagnosis of axial spondyloarthritis : 50 years after discovery of the strong genetic association].Zeitschrift fur Rheumatologie · 2024Review
- Unexpected High Need for Genetic Testing in Rheumatology: A Cross-Sectional Cohort Study.Genes · 2023Article
- HLA-B27 positivity in a large miscegenated population of 5,389,143 healthy blood marrow donors in Brazil.Advances in rheumatology (London, England) · 2023Article
- Genome-wide association study reveals ethnicity-specific SNPs associated with ankylosing spondylitis in the Taiwanese population.Journal of translational medicine · 2022Article
- Actual Associations between HLA Haplotype and Graves' Disease Development.Journal of clinical medicine · 2022Article
- Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers.Infection and immunity · 2022Article
- Age at onset in axial spondyloarthritis around the world: data from the Assessment in SpondyloArthritis international Society Peripheral Involvement in Spondyloarthritis study.Rheumatology (Oxford, England) · 2022Article
- Spondyloarthritides: Theories and beyond.Frontiers in pediatrics · 2022Review
- Structural aspects of chemical modifications in the MHC-restricted immunopeptidome; Implications for immune recognition.Frontiers in chemistry · 2022Review
- Enthesitis Related Arthritis in a Longitudinal Southeast Asian Registry: High Prevalence of HLA-B27, Different Sacroiliitis Risk Factors and Less Common Drug-Free Remission.Journal of clinical medicine · 2021Article
- Understanding the Pathogenesis of Spondyloarthritis.Biomolecules · 2020Review
- Variant in ERAP1 promoter region is associated with low expression in a patient with a Behçet-like MHC-I-opathy.Journal of human genetics · 2020Article
- The Influence of Vitamin D Receptor Gene Polymorphisms in Spondyloarthritis.International journal of inflammation · 2020Article
- Optimization of HLA-B*27 ALLELE Genotyping by PCR-SSP.Clinics (Sao Paulo, Brazil) · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HLA-B27 has a high degree of genetic polymorphism, with 105 known subtypes, named HLA-B*27:01 to HLA-B*27:106, encoded by 132 alleles. The most common subtypes associated with ankylosing spondylitis are HLA-B*27:05 (Caucasians), HLA-B*27:04 (Chinese), and HLA-B*27:02 (Mediterranean populations). For Chinese populations, HLA-B*27:04 is associated with a greater ankylosing spondylitis risk than HLA-B*27:05. Two subtypes, HLA-B27*06 and HLA-B27*09, seem to have no disease association. These differential disease associations of HLA-B27 subtypes, and the recent discovery that ERAP1 is associated with ankylosing spondylitis for patients with HLA-B27, have increased attempts to determine the function of HLA-B27 in disease pathogenesis by studying hemodynamic features of its protein structure, alterations of its peptidome, aberrant peptide handling, and associated molecular events. However, after 40 years we still do not fully know how HLA-B27 predisposes to ankylosing spondylitis and related spondyloarthritis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.