Evidence map›Paper›PMID 23990355›Full record

ArticleStatistical methods in medical research2016

Variable selection in semi-parametric models.

Hongmei Zhang, Arnab Maity, Hasan Arshad, John Holloway, Wilfried Karmaus

Abstract read
In one paragraph

Article in Statistical methods in medical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Unified variable selection in semi-parametric models.Statistical methods in medical research · 2017
    Article
  3. Multigenerational cohorts in patients with asthma and allergy.The Journal of allergy and clinical immunology · 2017
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Hongmei ZhangDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, TN, USA hzhang@sc.edu.
Arnab MaityDepartment of Statistics, North Carolina State University, NC, USA.
Hasan ArshadThe David Hide Asthma and Allergy Research Center, St. Marys Hospital, Isle of Wight, UK Allergy and Clinical Immunology, University of Southampton, Southampton, UK.
John HollowayFaculty of Medicine, University of Southampton, Southampton, UK.
Wilfried KarmausDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, TN, USA.
University of Memphis · USNorth Carolina State University · USSt. Mary's Hospital · GBUniversity of Southampton · GB

Funding

Transgenerational epigenetic inheritance of allergy in a multigenerational cohortR01AI091905 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KARMAUS, WILFRIED JJ · 2011 to 2015
$2.7M
Statistical Methods for Analysis of High-Dimensional Gene and Environment DataR00ES017744 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI MAITY, ARNAB · 2011 to 2013
$663k
NIAID NIH HHS R01 AI091905NIEHS NIH HHS R00 ES017744
6 · The paper itself

Abstract

We propose Bayesian variable selection methods in semi-parametric models in the framework of partially linear Gaussian and problit regressions. Reproducing kernels are utilized to evaluate possibly non-linear joint effect of a set of variables. Indicator variables are introduced into the reproducing kernels for the inclusion or exclusion of a variable. Different scenarios based on posterior probabilities of including a variable are proposed to select important variables. Simulations are used to demonstrate and evaluate the methods. It was found that the proposed methods can efficiently select the correct variables regardless of the feature of the effects, linear or non-linear in an unknown form. The proposed methods are applied to two real data sets to identify cytosine phosphate guanine methylation sites associated with maternal smoking and cytosine phosphate guanine sites associated with cotinine levels with creatinine levels adjusted. The selected methylation sites have the potential to advance our understanding of the underlying mechanism for the impact of smoking exposure on health outcomes, and consequently benefit medical research in disease intervention.

Indexed as

Bayes TheoremDNA MethylationEpistasis, GeneticLinear ModelsNormal DistributionCotinineCpG IslandsCreatinineCytochrome P-450 CYP1A1Datasets as TopicFemaleHumansMothersPregnancySmokingCotinineCreatinineCytochrome P-450 CYP1A1Bayesian methodsGaussian kernelnon-linear effectspartially linear regressionprobit regressionreproducing kernelvariable selection

Identifiers

PMID23990355
PMCPMC3938559
OpenAlexW2332814422

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.