ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Spatiotemporal properties of high-speed calcium oscillations in the pedunculopontine nucleus.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
- Comparing tonic and phasic dendritic calcium in cholinergic pedunculopontine neurons and dopaminergic substantia nigra neurons.The European journal of neuroscience · 2024Article
- Concerns regarding Baksa B, Kovacs A, Bayasgalan T, Szentesi P, Koseghy A, Szucs P, Balazs P. Characterization of functional subgroups among genetically identified cholinergic neurons in the pedunculopontine nucleus. Cell Molec. Life Sci. 2019-04-02.Cellular and molecular life sciences : CMLS · 2019Article
- Bottom-up gamma maintenance in various disorders.Neurobiology of disease · 2019Review
- Proteomic measures of gamma oscillations.Heliyon · 2019Article
- Focus on the pedunculopontine nucleus. Consensus review from the May 2018 brainstem society meeting in Washington, DC, USA.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019Review
- Local and Relayed Effects of Deep Brain Stimulation of the Pedunculopontine Nucleus.Brain sciences · 2019Review
- Bottom-up gamma and bipolar disorder, clinical and neuroepigenetic implications.Bipolar disorders · 2019Review
- Review
- Article
- Arousal and drug abuse.Behavioural brain research · 2017Review
- Bottom-up gamma and stages of waking.Medical hypotheses · 2017Article
- Recording Gamma Band Oscillations in Pedunculopontine Nucleus Neurons.Journal of visualized experiments : JoVE · 2016Article
- Implications of gamma band activity in the pedunculopontine nucleus.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Intracellular mechanisms modulating gamma band activity in the pedunculopontine nucleus (PPN).Physiological reports · 2016Article
- Kinetic regulation of multi-ligand binding proteins.BMC systems biology · 2016Article
- Arousal and the control of perception and movement.Current trends in neurology · 2016Article
- Bottom-up Gamma: the Pedunculopontine Nucleus and Reticular Activating System.Translational brain rhythmicity · 2016Article
- Pedunculopontine Gamma Band Activity and Development.Brain sciences · 2015Review
- Pedunculopontine arousal system physiology - Deep brain stimulation (DBS).Sleep science (Sao Paulo, Brazil) · 2015Review
- High-threshold Ca2+ channels behind gamma band activity in the pedunculopontine nucleus (PPN).Physiological reports · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The pedunculopontine nucleus (PPN) is a component of the reticular activating system (RAS), and is involved in the activated states of waking and rapid eye movement (REM) sleep. Gamma oscillations (approximately 30-80 Hz) are evident in all PPN neurons and are mediated by high-threshold voltage-dependent N- and P/Q-type calcium channels. We tested the hypothesis that high-speed calcium imaging would reveal calcium-mediated oscillations in dendritic compartments in synchrony with patch-clamp recorded oscillations during depolarizing current ramps. Patch-clamped 8- to 16-day-old rat PPN neurons (n = 67 out of 121) were filled with Fura 2, Bis Fura, or OGB1/CHR. This study also characterized a novel ratiometric technique using Oregon Green BAPTA-1 (OGB1) with coinjections of a new long-stokes-shift dye, Chromeo 494 (CHR). Fluorescent calcium transients were blocked with the nonspecific calcium channel blocker cadmium, or by the combination of ω-agatoxin-IVA, a specific P/Q-type calcium channel blocker, and ω-conotoxin-GVIA, a specific N-type calcium channel blocker. The calcium transients were evident in different dendrites (suggesting channels are present throughout the dendritic tree) along the sampled length without interruption (suggesting channels are evenly distributed), and appeared to represent a summation of oscillations present in the soma. We confirm that PPN calcium channel-mediated oscillations are due to P/Q- and N-type channels, and reveal that these channels are distributed along the dendrites of PPN cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.