ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Mapping cyclic stretch in the postpneumonectomy murine lung.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Diaphragm-Directed Strategies for Prolonged Air Leak Prevention After Lung Resection: A Narrative Review of the Residual Pleural Space Paradigm.Journal of clinical medicine · 2026Review
- Angiogenesis in Lung Regeneration and Aging.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Paxillin in mechanosensitive spatial control of lung endothelial cell regeneration.NPJ Regenerative medicine · 2026Article
- Evaluation of ventilation at 10 °C as the optimal storage condition for donor lungs in a murine model.Scientific reports · 2026Article
- Alveolar epithelial paxillin in postnatal lung alveolar development.Biology open · 2025Article
- Intermediary Role of Lung Alveolar Type 1 Cells in Epithelial Repair upon Sendai Virus Infection.American journal of respiratory cell and molecular biology · 2022Article
- Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration.Frontiers in bioengineering and biotechnology · 2022Article
- Single-Cell Transcriptional Profiling of Cells Derived From Regenerating Alveolar Ducts.Frontiers in medicine · 2020Article
- Vascular Niche in Lung Alveolar Development, Homeostasis, and Regeneration.Frontiers in bioengineering and biotechnology · 2019Review
- Evidence for pleural epithelial-mesenchymal transition in murine compensatory lung growth.PloS one · 2017Article
- Deformation-induced transitional myofibroblasts contribute to compensatory lung growth.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Elastin Cables Define the Axial Connective Tissue System in the Murine Lung.Anatomical record (Hoboken, N.J. : 2007) · 2015Article
- Remodeling of alveolar septa after murine pneumonectomy.American journal of physiology. Lung cellular and molecular physiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
In many mammalian species, the removal of one lung [pneumonectomy (PNX)] is associated with the compensatory growth of the remaining lung. To investigate the hypothesis that parenchymal deformation may trigger lung regeneration, we used respiratory-gated micro-computed tomography scanning to create three-dimensional finite-element geometric models of the murine cardiac lobe with cyclic breathing. Models were constructed of respiratory-gated micro-computed tomography scans pre-PNX and 24 h post-PNX. The computational models demonstrated that the maximum stretch ratio map was patchy and heterogeneous, particularly in subpleural, juxta-diaphragmatic, and cephalad regions of the lobe. In these parenchymal regions, the material line segments at peak inspiration were frequently two- to fourfold greater after PNX; some regions of the post-PNX cardiac lobe demonstrated parenchymal compression at peak inspiration. Similarly, analyses of parenchymal maximum shear strain demonstrated heterogeneous regions of mechanical stress with focal regions demonstrating a threefold increase in shear strain after PNX. Consistent with previously identified growth patterns, these subpleural regions of enhanced stretch and shear strain are compatible with a mechanical signal, likely involving cyclic parenchymal stretch, triggering lung growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.