ArticleNeuroscience bulletin2013
Stimulus discrimination via responses of retinal ganglion cells and dopamine-dependent modulation.
Article in Neuroscience bulletin, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Coding Properties of Mouse Retinal Ganglion Cells with Dual-Peak Patterns with Respect to Stimulus Intervals.Frontiers in computational neuroscience · 2016Article
- Effects of dopamine on response properties of ON-OFF RGCs in encoding stimulus durations.Frontiers in neural circuits · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neighboring retinal ganglion cells (RGCs) fire with a high degree of correlation. It has been increasingly realized that visual perception of the environment relies on neuronal population activity to encode and transmit the information contained in stimuli. Understanding how neuronal population activity contributes to visual information processing is essential for understanding the mechanisms of visual coding. Here we simultaneously recorded spike discharges from groups of RGCs in bullfrog retina in response to visual patterns (checkerboard, horizontal grating, and full-field illumination) using a multi-electrode array system. To determine the role of synchronous activity mediated by gap junctions, we measured the correct classification rates of single cells' firing patterns as well as the synchronization patterns of multiple neurons. We found that, under normal conditions, RGC population activity exhibited distinct response features with exposure to different stimulus patterns and had a higher rate of correct stimulus discrimination than the activity of single cells. Dopamine (1 μmol/L) application did not significantly change the performance of single neuron activity, but enhanced the synchronization of the RGC population activity and decreased the rate of correct stimulus pattern discrimination. These findings suggest that the synchronous activity of RGCs plays an important role in the information coding of different types of visual patterns, and a dopamine-induced increase in synchronous activity weakens the population performance in pattern discrimination, indicating the potential role of the dopaminergic pathway in modulating the population coding process.
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Registered trials
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