Trial reportJournal of assisted reproduction and genetics2013
Percutaneous epididymal sperm aspiration and short time insemination in the treatment of men with obstructive azoospermia.
Trial report in Journal of assisted reproduction and genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Comparing the pregnancy outcomes of Re‑ICSI and ICSI embryos in fresh ET and FET cycles.Biomedical reports · 2023Article
- Pregnancy outcome and follow-up of offspring of donor oocytes recipient from PCOS patients.BMC pregnancy and childbirth · 2022Article
- Genetic analysis of recurrent parthenogenesis: A case report and literature review.Experimental and therapeutic medicine · 2022Article
- Frozen blastocysts: Assessing the importance of day 5/day 6 blastocysts or blastocyst quality.Experimental and therapeutic medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the efficacy of percutaneous epididymal sperm aspiration (PESA) in combination with short time insemination to treat infertile men with obstructive azoospermia (OA).
designPaired randomized controlled trial in which each couple's cohort of oocytes was divided into two equal groups.
settingCenter for reproductive care. PATIENTS: Twenty men with OA.
interventionsMotile spermatozoa were collected using PESA. Half of the oocytes were used for intracytoplasmic sperm injection (ICSI). The rest were inseminated briefly with PESA sperm in vitro fertilization (IVF). After 4-5 h, the remaining cumulus cells were removed mechanically for second polar body observation to decide whether to apply "rescue" ICSI (RE-ICSI).
main outcome measuresRates of oocyte maturation, fertilization, cleavage, and good quality embryos. Numbers of available embryos and good quality embryos were compared between PESA-IVF (using a short incubation protocol + rescue ICSI) group and PESA-ICSI group.
resultsIn the short time insemination group, cumulus cells were dispersed by PESA spermatozoa. No second polar bodies were found, so RE-ICSI was done. PESA-IVF + RE-ICSI and PESA-ICSI outcomes were comparable in terms of fertilization rates, 2PN cleavage rate and good quality embryo rates with no statistically significant differences.
conclusionsPESA sperm without centrifugation could disperse the cumulus cells but were infertile and therefore could substitute for synthetic hyaluronidase. The outcomes of PESA-IVF with rescue ICSI were equivalent to PESA-ICSI. Using spermatozoa obtained by PESA and IVF before RE-ICIS is a viable treatment for men with OA.
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