ArticleScience (New York, N.Y.)2013
Opposite feedbacks in the Hippo pathway for growth control and neural fate.
Article in Science (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed.
- Active repression of muscle fate preserves neural lineage identity during cerebellum development.bioRxiv : the preprint server for biology · 2026Article
- miR-927 Regulates Photoreceptor Subtype Specification Through Yorkie and Sensory Opsins inCells · 2026Article
- Targeting the Hippo pathway in cancer.Nature reviews. Drug discovery · 2025Review
- Cell fate ratios are encoded by transcriptional dynamics in the Drosophila retina.Current biology : CB · 2025Article
- Traffic Jam activates the Flamenco piRNA cluster locus and the Piwi pathway to ensure transposon silencing and Drosophila fertility.Cell reports · 2025Article
- Assembling a Hippo: the evolutionary emergence of an animal developmental signaling pathway.Trends in biochemical sciences · 2024Review
- Functional opsin patterning for Drosophila color vision is established through signaling pathways in adjacent object-detection neurons.Development (Cambridge, England) · 2024Article
- The Interaction of Mechanics and the Hippo Pathway inCancers · 2023Article
- Systemic coagulopathy promotes host lethality in a new Drosophila tumor model.Current biology : CB · 2023Article
- Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling.iScience · 2023Article
- Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye.Developmental cell · 2023Article
- Blimp-1/PRDM1 and Hr3/RORβ specify the blue-sensitive photoreceptor subtype inFrontiers in cell and developmental biology · 2023Article
- Protein Phosphatase 2A with B' specificity subunits regulates the Hippo-Yorkie signaling axis in the Drosophila eye disc.Journal of cell science · 2022Article
- Tissue-specific regulation of translational readthrough tunes functions of the traffic jam transcription factor.Nucleic acids research · 2022Article
- The power of the (imperfect) palindrome: Sequence-specific roles of palindromic motifs in gene regulation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Review
- The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.PLoS genetics · 2021Article
- Article
- Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.PLoS genetics · 2021Article
- The Molecular Network of YAP/Yorkie at the Cell Cortex and their Role in Ocular Morphogenesis.International journal of molecular sciences · 2020Review
- Identification of Genes Involved in the Differentiation of R7y and R7p Photoreceptor Cells inG3 (Bethesda, Md.) · 2020Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Signaling pathways are reused for multiple purposes in plant and animal development. The Hippo pathway in mammals and Drosophila coordinates proliferation and apoptosis via the coactivator and oncoprotein YAP/Yorkie (Yki), which is homeostatically regulated through negative feedback. In the Drosophila eye, cross-repression between the Hippo pathway kinase LATS/Warts (Wts) and growth regulator Melted generates mutually exclusive photoreceptor subtypes. Here, we show that this all-or-nothing neuronal differentiation results from Hippo pathway positive feedback: Yki both represses its negative regulator, warts, and promotes its positive regulator, melted. This postmitotic Hippo network behavior relies on a tissue-restricted transcription factor network-including a conserved Otx/Orthodenticle-Nrl/Traffic Jam feedforward module-that allows Warts-Yki-Melted to operate as a bistable switch. Altering feedback architecture provides an efficient mechanism to co-opt conserved signaling networks for diverse purposes in development and evolution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.