Evidence map›Paper›PMID 23989802›Full record

ReviewGut microbes

Diet, microbial virulence, and Helicobacter pylori-induced gastric cancer.

Timothy L Cover, Richard M Peek

Open access · bronzeAbstract readReview
In one paragraph

Review in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 111 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. The prevalence and risk factors ofMicrobiota in health and disease · 2024
    Article
  8. Article
  9. Review
  10. Risk factors ofAnnals of medicine and surgery (2012) · 2023
    Article
  11. A Positively SelectedInfection and immunity · 2023
    Article
  12. Article
  13. Review
  14. Animal Models andJournal of clinical medicine · 2022
    Review
  15. Article
  16. Virulence Genes ofCanadian journal of gastroenterology & hepatology · 2022
    Article
  17. Ferroptosis and its Role in Gastric Cancer.Frontiers in cell and developmental biology · 2022
    Review
  18. Article
  19. Interdisciplinary insights into the link between gut microbiome and gastric carcinogenesis-what is currently known?Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2022
    Review
  20. Overview ofDiseases (Basel, Switzerland) · 2021
    Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Timothy L CoverDivision of Infectious Diseases; Vanderbilt University School of Medicine; Nashville, TN USA; Department of Pathology, Microbiology, and Immunology; Vanderbilt University School of Medicine; Nashville, TN USA; Veterans Affairs Tennessee Valley Healthcare System; Nashville, TN USA.
Richard M PeekDivision of Gastroenterology, Department of Medicine; Vanderbilt University School of Medicine; Nashville, TN USA.
Vanderbilt University · US

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Role of Iron and B-Catenin Activation in Gastric CarcinogenesisP01CA116087 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kevin L Schey · 2009 to 2026
$27.5M
Structure-function analysis of H. pylori VacAR01AI039657 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TIMOTHY L COVER · 1996 to 2026
$8.3M
Helicobacter Pylori and Gastrointestinal BiologyR01DK058587 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PEEK, RICHARD M. · 2001 to 2024
$7.8M
Analysis of the H. Pylori cag pathogenicity islandR01AI068009 · NIAID · VANDERBILT UNIVERSITY · PI COVER, TIMOTHY L · 2008 to 2012
$1.9M
Receptor-mediated actions of renin in kidney fibrosisK01DK077955 · NIDDK · UNIVERSITY OF UTAH · PI HUANG, YUFENG · 2008 to 2012
$653k
NCI NIH HHS CA-116087NCI NIH HHS P01 CA116087NIAID NIH HHS AI-039657NIAID NIH HHS AI- 068009NIAID NIH HHS R01 AI039657NIDDK NIH HHS DK-058404NIDDK NIH HHS DK-58587NIDDK NIH HHS DK-77955NIDDK NIH HHS K01 DK077955NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK058587
6 · The paper itself

Abstract

Gastric adenocarcinoma is a leading cause of cancer-related death worldwide, and Helicobacter pylori infection is one of the strongest known risk factors for this malignancy. H. pylori strains exhibit a high level of genetic diversity, and the risk of gastric cancer is higher in persons carrying certain strain types (for example, those that contain a cag pathogenicity island or type s1 vacA alleles) than in persons carrying other strain types. Additional risk factors for gastric cancer include specific human genetic polymorphisms and specific dietary preferences (for example, a high-salt diet or a diet deficient in fruits and vegetables). Finally, iron-deficiency anemia is a risk factor for gastric cancer. Recent studies have provided evidence that several dietary risk factors for gastric cancer directly impact H. pylori virulence. In this review article, we discuss mechanisms by which diet can modulate H. pylori virulence and thereby influence gastric cancer risk.

Indexed as

DietAnemia, Iron-DeficiencyAnimalsCholesterol, DietaryDisease Models, AnimalHelicobacter InfectionsHelicobacter pyloriHost-Pathogen InteractionsHumansIronMeta-Analysis as TopicRisk FactorsSmokingSodium, DietaryStomach NeoplasmsVirulenceCholesterol, DietaryIronSodium, DietaryVirulence FactorsBabACagAcagpathogenicity islanddietgastric adenocarcinomagastric cancerironsaltVacA

Identifiers

PMID23989802
PMCPMC3928160
OpenAlexW2040412134

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.