ArticleMarine drugs2013
Natural and semisynthetic analogues of manadoperoxide B reveal new structural requirements for trypanocidal activity.
Article in Marine drugs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Tides of Promise: Sponge-Derived Marine Natural Products in Southeast Asia.Molecules (Basel, Switzerland) · 2026Review
- Indonesian marine and its medicinal contribution.Natural products and bioprospecting · 2023Review
- Chemical and biological diversity of new natural products from marine sponges: a review (2009-2018).Marine life science & technology · 2022Review
- Promising antiparasitic agents from marine sponges.Saudi journal of biological sciences · 2022Review
- Review
- Chemistry and Selective Tumor Cell Growth Inhibitory Activity of Polyketides from the South China Sea Sponge Plakortis sp.Marine drugs · 2017Article
- The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases.Molecules (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), bearing some interesting relationships with the polyketide endoperoxides found in this sponge. Some semi-synthetic analogues of manadoperoxide B (6-8) were prepared and evaluated for antitrypanosomal activity and cytotoxicity. These studies revealed crucial structure-activity relationships that should be taken into account in the design of optimized and simplified endoperoxyketal trypanocidal agents.
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Registered trials
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