Evidence map›Paper›PMID 23989498›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2014

Multimodal exercise training during myeloablative chemotherapy: a prospective randomized pilot trial.

Karin Oechsle, Zeynep Aslan, Yvonne Suesse, Wiebke Jensen, Carsten Bokemeyer, Maike de Wit

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 15 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06134297 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Adherence, Feasibility, Clinical Evolution Therapeutic Efficacy of Three Different Muscle Overload Models Used for Physical Rehabilitation of Patients Undergoing Bone Marrow Transplantation: a Randomized Clinical Trial

TypeinterventionalSponsorFederal University of Health Science of Porto AlegreRan2022 to 2024Enrolled93ConditionsStem Cell TransplantationArmsCycle ergometer, Strength Training - elastic band and shin guards, Cycle ergometer, elastic band and shin guards
NCT07390071 narecruitingnot on this mapstarted 2025, after this paper: background citation

Multimodal Telerehabilitation in Patients Undergoing CAR-T Cell Immunotherapy

TypeinterventionalSponsorUniversity of UtahRan2025 to 2029Enrolled40ConditionsLymphoma, Myeloma, Cytokine Release Syndrome, Immune Effector Cell Associated Neurotoxicity SyndromeArmsHome Automated Telemanagement (HAT) Patient Unit
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 15 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Safety, feasibility, and effectiveness of exercise interventions in patients with hematologic malignancy during chemotherapy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  4. Physical rehabilitation for the management of cancer-related fatigue during cytotoxic treatment: a systematic review with meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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  8. Guideline
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  12. A systematic review of the safety and efficacy of aerobic exercise during cytotoxic chemotherapy treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
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  13. Safety and feasibility of exercise interventions in patients with advanced cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017
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  16. Therapeutic Exercise Protocol During Hospitalization in Pediatric Oncohematological Patients: Randomized Clinical Trial.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
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  19. Exercise and stress management training prior to hematopoietic cell transplantation: Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0902.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2014
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Karin OechslePneumology Section, Department of Oncology, Hematology and Bone Marrow Transplantation, University Medical Center Eppendorf, Hamburg, Germany.
Zeynep Aslan
Yvonne Suesse
Wiebke Jensen
Carsten Bokemeyer
Maike de Wit
University Medical Center Hamburg-Eppendorf · DEVivantes Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCancer and its treatment-related side effects induce loss of physical performance. This study evaluated the effects of multimodal aerobic and strength exercises on physical performance in hospitalized cancer patients while receiving myeloablative chemotherapy.

methodsIn this prospective pilot study, 48 evaluable patients were randomly assigned to a training (TG, n = 24) or control (CG, n = 24) group. The TG performed an individually supervised exercise program five times a week with ergometer training and strength exercises for 20 min each during the hospitalization period for chemotherapy. The CG received standard physiotherapy. Physical performance was evaluated using spiroergometry, lung function, and muscle strength testing. Treatment-related side effects were assessed by daily interviews, quality of life by EORTC-QLQ-C30, and fatigue using the Modified Fatigue Impact Scale (MFIS) questionnaire.

resultsPhysical performance significantly increased in the TG (8.96 ± 24 W) and decreased in the CG (-7.24 ± 20 W, p = 0.02). At 2-mmol/ml blood lactate concentration, the TG achieved significantly increased oxygen consumption (p = 0.03) and expiratory minute ventilation (p = 0.04) compared to the CG. Furthermore, physical functioning increased significantly in the TG (p = 0.04). Patients in the TG required less antiemetics (p = 0.01) and experienced significantly less fatigue (p = 0.04), although MFIS analysis was not able to detect this beneficial effect. Patients of the CG displayed higher impairments of cognitive (p = 0.02) and psychosocial function (p = 0.03) after chemotherapy. No adverse events due to the study intervention were observed.

conclusionsMultimodal exercise has beneficial effects on physical performance, physical functioning, and treatment-related symptoms even during myeloablative chemotherapy. We suggest an enhanced physical activity intervention program during hospitalization of cancer patients.

Indexed as

AdultAgedCombined Modality TherapyErgometryExercise TherapyFatigueFemaleHematologic NeoplasmsHumansMaleMiddle AgedOxygen ConsumptionPeripheral Blood Stem Cell TransplantationPilot ProjectsProspective StudiesQuality of Life

Identifiers

PMID23989498
OpenAlexW2397259442

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.