ArticleLeukemia2014
The murine long-term multi-lineage renewal marrow stem cell is a cycling cell.
Article in Leukemia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- The Essence of Quiescence.Stem cells and development · 2024Review
- LinCell proliferation · 2023Article
- The universal stem cell.Leukemia · 2022Review
- Expansion of Quiescent Hematopoietic Stem Cells under Stress and Nonstress Conditions in Mice.Stem cell reviews and reports · 2022Article
- Differentiation Epitopes Define Hematopoietic Stem Cells and Change with Cell Cycle Passage.Stem cell reviews and reports · 2022Article
- Article
- Heuristic bias in stem cell biology.Stem cell research & therapy · 2019Article
- Dissection of Signaling Events Downstream of the c-Mpl Receptor in Murine Hematopoietic Stem Cells Via Motif-Engineered Chimeric Receptors.Stem cell reviews and reports · 2018Article
- TLR5 signaling in murine bone marrow induces hematopoietic progenitor cell proliferation and aids survival from radiation.Blood advances · 2017Article
- Hematopoietic Stem Cells: Uncomfortable Considerations.Current molecular biology reports · 2017Article
- A revisionist history of adult marrow stem cell biology or 'they forgot about the discard'.Leukemia · 2017Review
- Extended time-lapse in vivo imaging of tibia bone marrow to visualize dynamic hematopoietic stem cell engraftment.Leukemia · 2017Article
- Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells.Leukemia · 2016Article
- Therapeutic use of human renal progenitor cells for kidney regeneration.Nature reviews. Nephrology · 2015Review
- Stem cell divisions and cancer.Leukemia · 2015Article
- Concise reviews: A stem cell apostasy: a tale of four H words.Stem cells (Dayton, Ohio) · 2015Review
- Reconsidering marrow stem cell cycle status: insights into an actively cycling hematopoietic stem cell population.Leukemia supplements · 2014Article
- Superior long-term repopulating capacity of G-CSF+plerixafor-mobilized blood: implications for stem cell gene therapy by studies in the Hbb(th-3) mouse model.Human gene therapy methods · 2014Article
- Adult marrow hematopoiesis: a continuum of change.Leukemia supplements · 2014Article
- Marrow Hematopoietic Stem Cells Revisited: They Exist in a Continuum and are Not Defined by Standard Purification Approaches; Then There are the Microvesicles.Frontiers in oncology · 2014Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Prevailing wisdom holds that hematopoietic stem cells (HSCs) are predominantly quiescent. Although HSC cycle status has long been the subject of scrutiny, virtually all marrow stem cell research has been based on studies of highly purified HSCs. Here we explored the cell cycle status of marrow stem cells in un-separated whole bone marrow (WBM). We show that a large number of long-term multi-lineage engraftable stem cells within WBM are in S/G2/M phase. Using bromodeoxyuridine, we show rapid transit through the cell cycle of a previously defined relatively dormant purified stem cell, the long-term HSC (LT-HSC; Lineage(-)/c-kit(+)/Sca-1(+)/Flk-2(-)). Actively cycling marrow stem cells have continually changing phenotype with cell cycle transit, likely rendering them difficult to purify to homogeneity. Indeed, as WBM contains actively cycling stem cells, and highly purified stem cells engraft predominantly while quiescent, it follows that the population of cycling marrow stem cells within WBM are lost during purification. Our studies indicate that both the discarded lineage-positive and lineage-negative marrow cells in a stem cell separation contain cycling stem cells. We propose that future work should encompass this larger population of cycling stem cells that is poorly represented in current studies solely focused on purified stem cell populations.
Indexed as
Identifiers
23989430What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.