ArticleAmerican journal of epidemiology2013
Prenatal exposure to traffic-related air pollution and risk of early childhood cancers.
Article in American journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02786420 (Imaging Innovations for Placental Assessment in Response to Environmental Pollution), which is not on this map. Cited by 53 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Imaging Innovations for Placental Assessment in Response to Environmental Pollution
Who cites it
53 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Exposure to outdoor air pollution at different periods and the risk of leukemia: a meta-analysis.Environmental science and pollution research international · 2021Pooled it
- Association between Outdoor Air Pollution and Childhood Leukemia: A Systematic Review and Dose-Response Meta-Analysis.Environmental health perspectives · 2019Pooled it
- A review and meta-analysis of outdoor air pollution and risk of childhood leukemia.Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews · 2015Pooled it
- Environmental and Occupational Risk Factors for Retinoblastoma.AJPM focus · 2026Review
- Exposure to outdoor ultrafine particle number concentrations and incidence of childhood cancer: A population-based cohort study.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Linking Air Pollution and Hematologic Malignancies: From Epidemiology to Molecular Mechanisms.Current hematologic malignancy reports · 2026Review
- Maternal residential proximity to oil and gas development in California and the risk of childhood cancer.International journal of hygiene and environmental health · 2026Article
- Influence of Social and Demographic Factors on Retinoblastoma Outcomes in the United States: A Systematic Review.Cochrane evidence synthesis and methods · 2026Review
- The association between air pollution exposure and childhood cancer: a scoping review about the challenges in epidemiological studies.BMC public health · 2025Article
- Ambient Fine Particulate Matter, Residential Greenness, and Childhood Cancer Risk by Trimester of Exposure in Minnesota 2000 to 2014: A Case-Control Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988-2015).Environmental health : a global access science source · 2025Article
- Air pollution and its impact on cancer incidence, cancer care and cancer outcomes.BMJ oncology · 2025Review
- Prenatal air pollution exposure is associated with inflammatory, cardiovascular, and metabolic biomarkers in mothers and newborns.Environmental research · 2024Article
- High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study.The Lancet. Planetary health · 2024Observational
- The complexities of PM2.5, greenspace, and childhood cancer.Journal of the National Cancer Institute · 2024Article
- Ambient air pollution and mortality: The role of socioeconomic conditions.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade.International journal of molecular sciences · 2024Article
- Neonatal per- and polyfluoroalkyl substance exposure in relation to retinoblastoma.Environmental research · 2024Article
- The neonatal blood spot metabolome in retinoblastoma.EJC paediatric oncology · 2023Article
- The effect of ambient air pollution on birth outcomes in Norway.BMC public health · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Exposure to air pollution during pregnancy has been linked to the risk of childhood cancer, but the evidence remains inconclusive. In the present study, we used land use regression modeling to estimate prenatal exposures to traffic exhaust and evaluate the associations with cancer risk in very young children. Participants in the Air Pollution and Childhood Cancers Study who were 5 years of age or younger and diagnosed with cancer between 1988 and 2008 were had their records linked to California birth certificates, and controls were selected from birth certificates. Land use regression-based estimates of exposures to nitric oxide, nitrogen dioxide, and nitrogen oxides were assigned based on birthplace residence and temporally adjusted using routine monitoring station data to evaluate air pollution exposures during specific pregnancy periods. Logistic regression models were adjusted for maternal age, race/ethnicity, educational level, parity, insurance type, and Census-based socioeconomic status, as well as child's sex and birth year. The odds of acute lymphoblastic leukemia increased by 9%, 23%, and 8% for each 25-ppb increase in average nitric oxide, nitrogen dioxide, and nitrogen oxide levels, respectively, over the entire pregnancy. Second- and third-trimester exposures increased the odds of bilateral retinoblastoma. No associations were found for annual average exposures without temporal components or for any other cancer type. These results lend support to a link between prenatal exposure to traffic exhaust and the risk of acute lymphoblastic leukemia and bilateral retinoblastoma.
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