ArticleMolecular and cellular biology1990
Ordered splicing of thymidine kinase pre-mRNA during the S phase of the cell cycle.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Non-sequential and multi-step splicing of the dystrophin transcript.RNA biology · 2016Article
- Pre-mRNA splicing: where and when in the nucleus.Trends in cell biology · 2011Review
- Retention of spliceosomal components along ligated exons ensures efficient removal of multiple introns.RNA (New York, N.Y.) · 2010Article
- Co-transcriptional splicing of constitutive and alternative exons.RNA (New York, N.Y.) · 2009Article
- Splicing of human immunodeficiency virus RNA is position-dependent suggesting sequential removal of introns from the 5' end.Nucleic acids research · 2005Article
- Rare autosomal recessive cardiac valvular form of Ehlers-Danlos syndrome results from mutations in the COL1A2 gene that activate the nonsense-mediated RNA decay pathway.American journal of human genetics · 2004Article
- The splicing of U12-type introns can be a rate-limiting step in gene expression.The EMBO journal · 2002Article
- Redefinition of exon 7 in the COL1A1 gene of type I collagen by an intron 8 splice-donor-site mutation in a form of osteogenesis imperfecta: influence of intron splice order on outcome of splice-site mutation.American journal of human genetics · 1999Article
- Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant.Journal of virology · 1998Article
- Splicing signals are required for S-phase regulation of the mouse thymidylate synthase gene.Molecular and cellular biology · 1996Article
- Lack of an effect of the efficiency of RNA 3'-end formation on the efficiency of removal of either the final or the penultimate intron in intact cells.Molecular and cellular biology · 1995Article
- Order of intron removal during splicing of endogenous adenine phosphoribosyltransferase and dihydrofolate reductase pre-mRNA.Molecular and cellular biology · 1993Article
- Introns are essential for growth-regulated expression of the mouse thymidylate synthase gene.Molecular and cellular biology · 1993Article
- Presence of regulatory sequences within intron 2 of the mouse thymidine kinase gene.Nucleic acids research · 1991Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Concomitant with the onset of S phase, a series of thymidine kinase (TK) splicing intermediates as well as mature TK mRNA accumulates in the nucleus of BALB/c 3T3 cells. Most of the TK splicing intermediates are retained by oligo(dT)-cellulose chromatography, and, therefore, 3' end formation and polyadenylation probably precede the splicing of TK pre-mRNAs. We have further characterized the TK pre-mRNAs that are present in the nuclei of S-phase cells by using specific probes derived from each of the six TK intervening sequences. Based on the sizes of the pre-mRNAs and their patterns of hybridization with these intron probes, we propose a pathway for intron removal from nascent TK transcripts. Intron excision occurred by a preferred, but not necessarily obligatory, order which appears to have been conserved in mouse and Chinese hamster cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.