ArticleAnnals of surgery2013
Long-term maturation of congenital diaphragmatic hernia treatment results: toward development of a severity-specific treatment algorithm.
Article in Annals of surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Use of an endo fascial closure device for thoracoscopic patch repair of congenital diaphragmatic hernia.Frontiers in pediatrics · 2026Article
- Article
- The efficacy of the postnatal nasogastric tube position as a prognostic marker of left-sided isolated congenital diaphragmatic hernia.Pediatric surgery international · 2022Article
- A new simplified technique in thoracoscopic repair of congenital diaphragmatic hernia.Pediatric surgery international · 2022Article
- Repair of congenital diaphragmatic hernia on extracorporeal membrane oxygenation - observations of a paediatric surgeon.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2022Article
- Optimal timing of surgery in infants with prenatally diagnosed isolated left-sided congenital diaphragmatic hernia: a multicenter, cohort study in Japan.Surgery today · 2021Article
- Human induced pluripotent stem cell-derived lung organoids in an ex vivo model of the congenital diaphragmatic hernia fetal lung.Stem cells translational medicine · 2021Article
- Education of pediatric surgery residents over time: Examining 15 years of case logs.Journal of pediatric surgery · 2021Article
- Congenital diaphragmatic eventration and hernia sac compared to CDH with true defects: a retrospective cohort study.European journal of pediatrics · 2020Article
- Extracorporeal Membrane Oxygenation in Congenital Diaphragmatic Hernia.Frontiers in pediatrics · 2019Review
- Controversies in extracorporeal membrane oxygenation (ECMO) utilization and congenital diaphragmatic hernia (CDH) repair using a Delphi approach: from the American Pediatric Surgical Association Critical Care Committee (APSA-CCC).Pediatric surgery international · 2018Article
- Congenital diaphragmatic hernia, management in the newborn.Pediatric surgery international · 2015Review
- Outcomes in the physiologically most severe congenital diaphragmatic hernia (CDH) patients: Whom should we treat?Journal of pediatric surgery · 2015Article
- Extracorporeal life support in patients with congenital diaphragmatic hernia: how long should we treat?Journal of the American College of Surgeons · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo assess the impact of varying approaches to congenital diaphragmatic hernia (CDH) repair timing on survival and need for ECMO when controlled for anatomic and physiologic disease severity in a large consecutive series of patients with CDH.
backgroundOur publication of 60 consecutive patients with CDH in 1999 showed that survival was significantly improved by limiting lung inflation pressures and eliminating hyperventilation.
methodsWe retrospectively reviewed 268 consecutive patients with CDH, combining 208 new patients with the 60 previously reported. Management and ventilator strategy were highly consistent throughout. Varying approaches to surgical timing were applied as the series matured.
resultsPatients with anatomically less severe left liver-down CDH had significantly increased need for ECMO if repaired in the first 48 hours, whereas patients with more severe left liver-up CDH survived at a higher rate when repair was performed before ECMO. Overall survival of 268 patients was 78%. Survival was 88% for those without lethal associated anomalies. Of these, 99% of left liver-down CDH survived, 91% of right CDH survived, and 76% of left liver-up CDH survived.
conclusionsThis study shows that patients with anatomically less severe CDH benefit from delayed surgery whereas patients with anatomically more severe CDH may benefit from a more aggressive surgical approach. These findings show that patients respond differently across the CDH anatomic severity spectrum and lay the foundation for the development of risk-specific treatment protocols for patients with CDH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.