ArticleSocial cognitive and affective neuroscience2014
Dopamine beta-hydroxylase gene modulates individuals' empathic ability.
Article in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Assessing social cognition in patients with schizophrenia and healthy controls using the reading the mind in the eyes test (RMET): a systematic review and meta-regression.Psychological medicine · 2024Pooled it
- Cumulative Dopaminergic Genetic Effects on Empathy Development in Emerging Adults.Journal of youth and adolescence · 2025Article
- Research progress on the mechanisms of pain empathy.Ibrain · 2025Review
- Multifactor Dimensionality Reduction Analysis to Evaluate the Association of Dopamine Beta-Hydroxylase (DΒH) Polymorphisms with Susceptibility to Dementia (SADEM Study).Molecular neurobiology · 2023Article
- Pharmacogenetics of Addiction Therapy.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Behavioral aspects and neurobiological properties underlying medical cannabis treatment in Shank3 mouse model of autism spectrum disorder.Translational psychiatry · 2021Article
- Reduced Plasma Dopamine-β-Hydroxylase Activity Is Associated With the Severity of Bipolar Disorder: A Pilot Study.Frontiers in psychiatry · 2021Article
- Functional Polymorphisms in Oxytocin and Dopamine Pathway Genes and the Development of Dispositional Compassion Over Time: The Young Finns Study.Frontiers in psychology · 2021Article
- COMTVal158Met Genotype Affects Complex Emotion Recognition in Healthy Men and Women.Frontiers in neuroscience · 2018Article
- Structural Correlates of Reading the Mind in the Eyes in Autism Spectrum Disorder.Frontiers in human neuroscience · 2017Article
- Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents.European archives of psychiatry and clinical neuroscience · 2016Article
- A Preliminary Study of DBH (Encoding Dopamine Beta-Hydroxylase) Genetic Variation and Neural Correlates of Emotional and Motivational Processing in Individuals With and Without Pathological Gambling.Journal of behavioral addictions · 2016Article
- Structural Neural Substrates of Reading the Mind in the Eyes.Frontiers in human neuroscience · 2016Article
- Inter-individual relationships in empathic traits and feedback-related fronto-central brain activity: an event-related potential study.Journal of physiological anthropology · 2015Article
- Serotonin receptor gene (HTR2A) T102C polymorphism modulates individuals' perspective taking ability and autistic-like traits.Frontiers in human neuroscience · 2015Article
- The influence of COMT Val¹⁵⁸Met genotype on the character dimension cooperativeness in healthy females.Brain and behavior · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopamine beta-hydroxylase (DBH), an enzyme that converts dopamine to norepinephrine, has broad influences on social functions. In this study, we examined to what extent two polymorphisms (-1021C/T and a 19 bp insertion/deletion) in DBH gene modulate individuals' empathic perception and response, which were measured, respectively, by reading the mind in the eyes test and the empathic concern subscale of interpersonal reactivity index. Results showed that polymorphism at -1021C/T, but not the 19 bp insertion/deletion, accounts for 2.3% variance of empathic perception and 1.4% variance of empathic response. Individuals with the CC genotype, which is associated with higher DBH activity, manifested greater empathic ability than those with CT/TT genotypes. These findings demonstrate the importance of DBH -1021C/T as a genetic basis of empathy and in predicting individual differences in social and affective processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.