Evidence map›Paper›PMID 23988482›Full record

ReviewJournal of innate immunity2014

The Anopheles innate immune system in the defense against malaria infection.

April M Clayton, Yuemei Dong, George Dimopoulos

Abstract readReview
In one paragraph

Review in Journal of innate immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Role of microbiota in host-Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025
    Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. History of Mosquito Transgenesis: A Perspective in Review.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  19. Microbial gatekeepers: midgut bacteria inFrontiers in microbiology · 2025
    Review
  20. FromFrontiers in immunology · 2025
    Review

50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

April M ClaytonW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Md., USA.
Yuemei Dong
George Dimopoulos

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9M
Dissection of Anopheles Responses to Plasmodium Infected BloodR01AI061576 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DIMOPOULOS, GEORGE · 2005 to 2014
$3.8M
Dscam function in innate immunityR01AI081877 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DIMOPOULOS, GEORGE · 2010 to 2014
$1.6M
Aedes anti-dengue immunityR01AI078997 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DIMOPOULOS, GEORGE · 2009 to 2010
$805k
The JAK-STAT pathway in anti-dengue defenseR21AI090188 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DIMOPOULOS, GEORGE · 2010 to 2011
$448k
NIAID NIH HHS R01 AI061576NIAID NIH HHS R01 AI078997NIAID NIH HHS R01 AI081877NIAID NIH HHS R21 AI090188NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

The multifaceted innate immune system of insects is capable of fighting infection by a variety of pathogens including those causing human malaria. Malaria transmission by the Anopheles mosquito depends on the Plasmodium parasite's successful completion of its lifecycle in the insect vector, a process that involves interactions with several tissues and cell types as well as with the mosquito's innate immune system. This review will discuss our current understanding of the Anopheles mosquito's innate immune responses against the malaria parasite Plasmodium and the influence of the insect's intestinal microbiota on parasite infection.

Indexed as

AnimalsAnophelesHemocytesHost-Parasite InteractionsHumansImmunity, InnateInsect VectorsMalariaPlasmodiumSignal Transduction

Identifiers

PMID23988482
PMCPMC3939431

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.