Trial reportBMC medicine2013
Alcohol intake, wine consumption and the development of depression: the PREDIMED study.
Trial report in BMC medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05261620 (W.I.S.E.-Wine Implementation for Surgical Recovery Enhancement), which is not on this map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
W.I.S.E.-Wine Implementation for Surgical Recovery Enhancement
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.
- Resveratrol and Depression in Animal Models: A Systematic Review of the Biological Mechanisms.Molecules (Basel, Switzerland) · 2018Pooled it
- Risk Factors for Depression and Nomogram Prediction Among Chinese Coronary Heart Disease Patients: A Multi-Center Study from 2016 to 2018.International journal of general medicine · 2025Trial
- Drinking patterns and antidepressant medication - a prospective register-linked study among 40 to 60-year-old employees.Social psychiatry and psychiatric epidemiology · 2026Article
- Alcohol Consumption and DNA Methylation in a Mediterranean Cohort: A Focus on Oxidative Stress and Aging Biomarkers.Antioxidants (Basel, Switzerland) · 2026Article
- The relationship between diet quality, measured by the recommended food score, and depression, assessed using the Patient Health Questionnaire-9: an observational study in Korea.Korean journal of family medicine · 2026Article
- Depression, Functional Dependence, and Oral Health: Evidence from a Clinical Study of Older Spanish Adults.Diagnostics (Basel, Switzerland) · 2025Article
- Associations between flavonoid-rich food and flavonoid intakes and incident unhealthy aging outcomes in older United States males and females.The American journal of clinical nutrition · 2025Article
- Non-Alcoholic Wines: Sensory Pleasantness and Health Benefits.Foods (Basel, Switzerland) · 2025Review
- Adherence to the Mediterranean diet and risk of anxiety and depression in people with obesity: a cross-sectional analysis.European journal of clinical nutrition · 2025Article
- Analysis of the current status and associated factors of depressive symptoms in Chinese middle-aged and elderly stroke patients-based on CHARLS data.Frontiers in psychiatry · 2025Article
- The association of dietary components with depression and anxiety symptoms: findings from a cross-sectional survey.Frontiers in nutrition · 2025Article
- Bidirectional Associations Between Alcohol Drinking and Depressive Symptoms Among US Adults Aged 50 to 75: The US Health and Retirement Study.Healthcare (Basel, Switzerland) · 2024Article
- Association between alcohol drinking frequency and depression among adults in the United States: a cross-sectional study.BMC psychiatry · 2024Article
- Flavonoid-Rich Foods, Dementia Risk, and Interactions With Genetic Risk, Hypertension, and Depression.JAMA network open · 2024Article
- Fatigue or excessive daytime sleepiness: which is more closely related to depression?Sleep & breathing = Schlaf & Atmung · 2024Article
- Relationships between altitude and depressive symptoms among middle-aged and older adults in China: a longitudinal study from the China health and retirement longitudinal study.Frontiers in psychiatry · 2024Article
- The potential causal relationship between various lifestyles and depression: a univariable and multivariable Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Prevalence and Associated Factors of Depression among Adults Suffering from Migraine in Spain.Brain sciences · 2023Article
- Antidepressant-like Effects of Representative Types of Food and Their Possible Mechanisms.Molecules (Basel, Switzerland) · 2023Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlcoholic beverages are widely consumed. Depression, the most prevalent mental disorder worldwide, has been related to alcohol intake. We aimed to prospectively assess the association between alcohol intake and incident depression using repeated measurements of alcohol intake.
methodsWe followed-up 5,505 high-risk men and women (55 to 80 y) of the PREDIMED Trial for up to seven years. Participants were initially free of depression or a history of depression, and did not have any history of alcohol-related problems. A 137-item validated food frequency questionnaire administered by a dietician was repeated annually to assess alcohol intake. Participants were classified as incident cases of depression when they reported a new clinical diagnosis of depression, and/or initiated the use of antidepressant drugs. Cox regression analyses were fitted over 23,655 person-years.
resultsModerate alcohol intake within the range of 5 to 15 g/day was significantly associated with lower risk of incident depression (hazard ratio (HR) and 95% confidence interval (95% CI) = 0.72 (0.53 to 0.98) versus abstainers). Specifically, wine consumption in the range of two to seven drinks/week was significantly associated with lower rates of depression (HR (95% CI) = 0.68 (0.47 to 0.98)).
conclusionsModerate consumption of wine may reduce the incidence of depression, while heavy drinkers seem to be at higher risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.