ArticleAnnals of the American Thoracic Society2013
In-hospital acute stress symptoms are associated with impairment in cognition 1 year after intensive care unit admission.
Article in Annals of the American Thoracic Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 80 citations in OpenAlex.
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- Post-intensive Care Syndrome (PICS): an American Association for the Surgery of Trauma Critical Care Committee Consensus Guideline - Defining, Recognizing, and Managing PICS Associated Physical Impairment, Cognitive Dysfunction, and Thromboinflammatory Dysregulation.Trauma surgery & acute care open · 2026Article
- Trajectories of post-discharge cognitive function and associated risk factors in ICU survivors: a secondary analysis.Scientific reports · 2025Article
- Post-Traumatic Stress Disorder in ICU Survivors: Correlations with Long-Term Psychiatric and Physical Outcomes.International journal of environmental research and public health · 2025Article
- Article
- Assessment of neuropsychiatric manifestations in a cohort of intensive care unit survivors: A proof of concept study.Journal of the Intensive Care Society · 2023Article
- Functional and Clinical Characteristics of Individuals Attending Pulmonary Rehabilitation After Severe COVID-19.Respiratory care · 2023Article
- Author response to "post-infection cognitive impairments in a cohort of elderly patients with COVID-19".Molecular neurodegeneration · 2022Article
- To the editor: Response to post-infection cognitive impairments in a cohort of elderly patients with COVID-19, by Wang, Y.J. et al. (2021).Molecular neurodegeneration · 2022Article
- Patients' experiences of cognitive impairment following critical illness: a scoping review protocol.BMJ open · 2022Article
- The Feasibility and Validity of Objective and Patient-Reported Measurements of Cognition During Early Critical Illness Recovery.Neurocritical care · 2021Article
- Cognitive phenotypes 1 month after ICU discharge in mechanically ventilated patients: a prospective observational cohort study.Critical care (London, England) · 2020Observational
- Emotional Experiences and Coping Strategies of Family Members of Critically Ill Patients.Chest · 2020Article
- Article
- Post-intensive care syndrome: its pathophysiology, prevention, and future directions.Acute medicine & surgery · 2019Review
- Tailored multicomponent program for discomfort reduction in critically ill patients may decrease post-traumatic stress disorder in general ICU survivors at 1 year.Intensive care medicine · 2019Observational
- Article
- Improving Long-Term Outcomes After Sepsis.Critical care clinics · 2018Review
- Post-intensive Care Syndrome: an Overview.Journal of translational internal medicine · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
rationalePrior studies have found that cognitive dysfunction is common in intensive care unit (ICU) survivors. Yet, relatively little is known about potentially modifiable risk factors for longer-term post-ICU cognitive impairment.
objectivesTo determine if in-hospital acute stress symptoms were associated with impaired 12-month cognitive functioning among ICU survivors.
methodsWe prospectively enrolled 150 nontrauma patients without cognitive impairment or a dementia diagnosis who were admitted to an ICU for more than 24 hours. Patients were interviewed before hospital discharge and again via telephone at 12 months post-ICU. MEASUREMENTS AND MAIN
resultsDemographics and clinical information were obtained through medical record reviews and in-person interviews. In-hospital acute stress symptoms were assessed with the Posttraumatic Stress Disorder Checklist-Civilian Version. Twelve-month post-ICU cognition was assessed with the modified Telephone Interview for Cognitive Status. Follow-up interviews were completed with 120 (80%) patients. Patients' mean age at hospitalization was 48.2 years (SD, 13.7). In unadjusted analyses, a greater number of in-hospital acute stress symptoms was associated with significantly greater impairment in 12-month cognitive functioning (β, -0.1; 95% confidence interval, -0.2 to -0.004; P = 0.04). After adjusting for patient and clinical factors, in-hospital acute stress symptoms were independently associated with greater impairment in 12-month cognitive functioning (β, -0.1; 95% CI, -0.2 to -0.01; P = 0.03).
conclusionsIn-hospital acute stress symptoms may be a potentially modifiable risk factor for greater impairment in cognitive functioning post-ICU. Early interventions for at-risk ICU survivors may improve longer-term outcomes.
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