ArticleJournal of the American Chemical Society2013
Poly(iohexol) nanoparticles as contrast agents for in vivo X-ray computed tomography imaging.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Development of Pd-Loaded Hf-Based Metal-Organic Framework as a Dual-Modal Contrast Agent for Photoacoustic Imaging and Computed Tomography.ACS biomaterials science & engineering · 2025Article
- Article
- Nanomedicine for Diagnosis and Treatment of Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Nanoceria as Safe Contrast Agents for X-ray CT Imaging.Nanomaterials (Basel, Switzerland) · 2023Article
- Ultrasmall, elementary and highly translational nanoparticle X-ray contrast media from amphiphilic iodinated statistical copolymers.Acta pharmaceutica Sinica. B · 2023Article
- An iodide-containing covalent organic framework for enhanced radiotherapy.Chemical science · 2023Article
- Nanomaterial-based contrast agents.Nature reviews. Methods primers · 2023Article
- Polyethyleneimine-Based Drug Delivery Systems for Cancer Theranostics.Journal of functional biomaterials · 2022Review
- Increased Sensitivity of Computed Tomography Scan for Neoplastic Tissues Using the Extracellular Vesicle Formulation of the Contrast Agent Iohexol.Pharmaceutics · 2022Article
- Small-Molecule Bi-DOTA Complex for High-Performance CT and Spectral CT Bioimaging.Frontiers in oncology · 2022Article
- Organic Nanoplatforms for Iodinated Contrast Media in CT Imaging.Molecules (Basel, Switzerland) · 2021Review
- Seeing Better and Going Deeper in Cancer Nanotheranostics.International journal of molecular sciences · 2019Review
- Cyclic RGD-Functionalized and Disulfide-Crosslinked Iodine-Rich Polymersomes as a Robust and Smart Theranostic Agent for Targeted CT Imaging and Chemotherapy of Tumor.Theranostics · 2019Article
- Targeted tumor dual mode CT/MR imaging using multifunctional polyethylenimine-entrapped gold nanoparticles loaded with gadolinium.Drug delivery · 2018Article
- Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging.Scientific reports · 2018Article
- Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral CT technologies.Advanced drug delivery reviews · 2017Review
- Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2017Review
- A novel micro-CT-based method to monitor the morphology of blood vessels in the rabbit endplate.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017Article
- Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Biocompatible poly(iohexol) nanoparticles, prepared through cross-linking of iohexol and hexamethylene diisocyanate followed by coprecipitation of the resulting cross-linked polymer with mPEG-polylactide, were utilized as contrast agents for in vivo X-ray computed tomography (CT) imaging. Compared to conventional small-molecule contrast agents, poly(iohexol) nanoparticles exhibited substantially protracted retention within the tumor bed and a 36-fold increase in CT contrast 4 h post injection, which makes it possible to acquire CT images with improved diagnosis accuracy over a broad time frame without multiple administrations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.