ArticleInternational journal of circumpolar health2013
The frequency of HLA alleles in a population of Inuit women of northern Quebec.
Article in International journal of circumpolar health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Inuit HLA variation and neuroimmune disease.Frontiers in neuroscience · 2026Review
- Human Leukocyte Antigen-A, B, C, DRB1, and DQB1 Allele and Haplotype Frequencies in a Subset of 237 Donors in the South African Bone Marrow Registry.Journal of immunology research · 2018Article
- The frequency of HLA alleles in the Romanian population.Immunogenetics · 2016Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundHuman leukocyte antigen (HLA) alleles code for proteins that are involved in the recognition of foreign antigens and activation of the immune system. The frequency of HLA alleles varies across different populations.
objectiveTo describe the frequency of HLA alleles in a population of Inuit women of Nunavik, Quebec, Canada.
designA cohort of women was recruited from 4 different communities between January 2002 and December 2007. HLA-B*07, HLA-DQB1*03, DQB1*06:02, DRB1*13 and DRB1*15:01 alleles were typed by PCR sequence-specific primers (PCR-SSP) and HLA-E and G alleles were type by DNA-sequencing procedures.
resultsWe obtained data on 524 participants. The most frequent HLA alleles in this population were HLA-E*01:03, HLA-G*01:04:01 and HLA-DQB1*03, and they were found in 89, 75 and 94% of the population, respectively.
conclusionsThe distribution of HLA alleles in Nunavik, Quebec is unique when compared to other populations in Canada or around the world.
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