ArticleFrontiers in human neuroscience2013
The association between creativity and 7R polymorphism in the dopamine receptor D4 gene (DRD4).
Article in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 80 citations in OpenAlex.
- The 7-Repeat (7R) Variant of theInternational journal of molecular sciences · 2025Article
- Dopaminergic and Noradrenergic Contributions to Divergent and Convergent Creativity Task Performance, a Systematic Review.Behavioral sciences (Basel, Switzerland) · 2025Review
- The 7 Muses of Neuro-Creative Cycle: How some patients with Parkinson's disease can unleash latent creativity.AIMS neuroscience · 2025Article
- Memory reconsolidation: a proposed change mechanism for the arts therapies.Frontiers in cognition · 2025Article
- Creative thinking and cognitive estimation in Parkinson's disease.Neurological research and practice · 2024Article
- Dopamine supports idea originality: the role of spontaneous eye blink rate on divergent thinking.Psychological research · 2023Article
- Interdisciplinary Approach to Biological and Health Implications in Selected Professional Competences.Brain sciences · 2022Review
- The sexual selection of creativity: A nomological approach.Frontiers in psychology · 2022Review
- Subcortical structures and visual divergent thinking: a resting-state functional MRI analysis.Brain structure & function · 2021Article
- GPCR Pharmacological Profiling of Aaptamine from the Philippine SpongeMolecules (Basel, Switzerland) · 2021Article
- DRD4 Allele Frequency as a Lab Exercise in Neuroscience and Genetics Courses.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2021Article
- Cognitive flexibility and religious disbelief.Psychological research · 2019Article
- The Link Between Creativity, Cognition, and Creative Drives and Underlying Neural Mechanisms.Frontiers in neural circuits · 2019Review
- Dopamine Modulates Option Generation for Behavior.Current biology : CB · 2018Article
- Article
- Can Your DNA Influence Your Bet-Placing? The Impact of Cannabinoid Receptor 1 Gene on Gambling Tasks.Frontiers in human neuroscience · 2018Article
- Heritability of Working in a Creative Profession.Behavior genetics · 2017Article
- Decoding emotion of the other differs among schizophrenia patients and schizoaffective patients: A pilot study.Schizophrenia research. Cognition · 2016Article
- Article
- Dopamine and the Creative Mind: Individual Differences in Creativity Are Predicted by Interactions between Dopamine Genes DAT and COMT.PloS one · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Creativity can be defined as the ability to produce responses that are both novel and appropriate. One way to assess creativity is to measure divergent thinking (DT) abilities that involve generating multiple novel and meaningful responses to open-ended questions. DT abilities have been shown to be associated with dopaminergic (DA) activity, and impaired DT has been reported in populations with DA dysfunctions. Given the strong association between DT and the DA system, the current study examined a group of healthy individuals (N = 185) to determine the role of repeat polymorphism in exon3 of the DRD4 gene in creativity. The results show that individuals carrying the DRD4-7R allele scored significantly lower on tests of DT, particularly on the flexibility dimension of DT, compared to non-carriers. The current findings link creative cognition to the DA system and suggest that DA dysfunctions in neurological and psychiatric disorders may account for impaired creativity and cognitive flexibility in these individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.