ArticleJournal of cell science2013
The architectural relationship of components controlling mast cell endocytosis.
Article in Journal of cell science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Tetraspanin CD82 shapes EGFR signaling outcomes through nanoscale receptor organization.The Journal of cell biology · 2026Article
- The Uptake of Heparanase into Mast Cells Is Regulated by Its Enzymatic Activity to Degrade Heparan Sulfate.International journal of molecular sciences · 2024Article
- Structurally distinct endocytic pathways for B cell receptors in B lymphocytes.Molecular biology of the cell · 2020Article
- Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein.Frontiers in immunology · 2018Article
- New Regulatory Roles of Galectin-3 in High-Affinity IgE Receptor Signaling.Molecular and cellular biology · 2016Article
- Mast cells and dendritic cells form synapses that facilitate antigen transfer for T cell activation.The Journal of cell biology · 2015Article
- Unraveling a molecular determinant for clathrin-independent internalization of the M2 muscarinic acetylcholine receptor.Scientific reports · 2015Article
- Three dimensional time-gated tracking of non-blinking quantum dots in live cells.Proceedings of SPIE--the International Society for Optical Engineering · 2015Article
- Fluorogen-activating proteins provide tunable labeling densities for tracking FcεRI independent of IgE.ACS chemical biology · 2015Article
- Article
- Multi-protein assemblies underlie the mesoscale organization of the plasma membrane.Nature communications · 2014Article
- Regulation of fc receptor endocytic trafficking by ubiquitination.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Eukaryotic cells use multiple routes for receptor internalization. Here, we examine the topographical relationships of clathrin-dependent and clathrin-independent endocytic structures on the plasma membranes of leukemia-derived mast cells. The high affinity IgE receptor (FcεRI) utilizes both pathways, whereas transferrin receptor serves as a marker for the classical clathrin-mediated endocytosis pathway. Both receptors were tracked by live-cell imaging in the presence or absence of inhibitors that established their differential dependence on specific endocytic adaptor proteins. The topology of antigen-bound FcεRI, clathrin, dynamin, Arf6 and Eps15-positive structures were analyzed by 2D and 3D immunoelectron microscopy techniques, revealing their remarkable spatial relationships and unique geometry. We conclude that the mast cell plasma membrane has multiple specialized domains for endocytosis. Their close proximity might reflect shared components, such as lipids and adaptor proteins, that facilitate inward membrane curvature. Intersections between these specialized domains might represent sorting stations that direct cargo to specific endocytic pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.