ArticleJournal of cell science2013
ERK and phosphoinositide 3-kinase temporally coordinate different modes of actin-based motility during embryonic wound healing.
Article in Journal of cell science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Platelet-derived growth factor receptor alpha regulates fetal testis differentiation via an ERK-CREB axis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Umbelliferone preserves skin epidermal barrier integrity in diabetes-induced keratinocytes by regulating actin dynamics and suppressing ROS-mediated apoptosis.Nutrition & diabetes · 2025Article
- Mechanical cues polarize ADIP protein complexes to control vertebrate morphogenesis and wound healing.Current biology : CB · 2025Article
- β-adrenergic receptor regulates embryonic epithelial extensibility through actomyosin inhibition.iScience · 2023Article
- Electric field-guided collective motility initiation of large epidermal cell groups.Molecular biology of the cell · 2023Article
- Epidermal growth factor receptor signaling protects epithelia from morphogenetic instability and tissue damage in Drosophila.Development (Cambridge, England) · 2023Article
- Regulation of gene expression downstream of a novel Fgf/Erk pathway during Xenopus development.PloS one · 2023Article
- Article
- Intracellular signaling dynamics and their role in coordinating tissue repair.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- CaCells · 2020Review
- Integrin β1 in Adipose-Derived Stem Cells Accelerates Wound Healing via Activating PI3K/AKT Pathway.Tissue engineering and regenerative medicine · 2020Article
- The role of nitric oxide during embryonic wound healing.BMC genomics · 2019Article
- Forceful closure: cytoskeletal networks in embryonic wound repair.Molecular biology of the cell · 2019Review
- The MicroRNA miR-155 Is Essential in Fibrosis.Non-coding RNA · 2019Review
- Article
- Article
- Fast DynamicFrontiers in cell and developmental biology · 2018Article
- Astaxanthin induces migration in human skin keratinocytes via Rac1 activation and RhoA inhibition.Nutrition research and practice · 2017Article
- Rab14 specifies the apical membrane through Arf6-mediated regulation of lipid domains and Cdc42.Scientific reports · 2016Article
- The actin cable is dispensable in directing dorsal closure dynamics but neutralizes mechanical stress to prevent scarring in the Drosophila embryo.Nature cell biology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Embryonic wound healing provides a perfect example of efficient recovery of tissue integrity and homeostasis, which is vital for survival. Tissue movement in embryonic wound healing requires two functionally distinct actin structures: a contractile actomyosin cable and actin protrusions at the leading edge. Here, we report that the discrete formation and function of these two structures is achieved by the temporal segregation of two intracellular upstream signals and distinct downstream targets. The sequential activation of ERK and phosphoinositide 3-kinase (PI3K) signalling divides Xenopus embryonic wound healing into two phases. In the first phase, activated ERK suppresses PI3K activity, and is responsible for the activation of Rho and myosin-2, which drives actomyosin cable formation and constriction. The second phase is dominated by restored PI3K signalling, which enhances Rac and Cdc42 activity, leading to the formation of actin protrusions that drive migration and zippering. These findings reveal a new mechanism for coordinating different modes of actin-based motility in a complex tissue setting, namely embryonic wound healing.
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Registered trials
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