ArticleJournal of cell science2013
Centromeric motion facilitates the mobility of interphase genomic regions in fission yeast.
Article in Journal of cell science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Integrative modeling of the genome structure and dynamics in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells.Protein & cell · 2022Article
- Potential roles of condensin in genome organization and beyond in fission yeast.Journal of microbiology (Seoul, Korea) · 2021Review
- Nuclear Mechanics in the Fission Yeast.Cells · 2019Review
- Effects of the microtubule nucleator Mto1 on chromosomal movement, DNA repair, and sister chromatid cohesion in fission yeast.Molecular biology of the cell · 2019Article
- Architectural alterations of the fission yeast genome during the cell cycle.Nature structural & molecular biology · 2017Article
- Transcription factors mediate condensin recruitment and global chromosomal organization in fission yeast.Nature genetics · 2016Article
- Involvement of condensin-directed gene associations in the organization and regulation of chromosome territories during the cell cycle.Nucleic acids research · 2016Article
- An IF-FISH Approach for Covisualization of Gene Loci and Nuclear Architecture in Fission Yeast.Methods in enzymology · 2016Article
- Chromosome domain architecture and dynamic organization of the fission yeast genome.FEBS letters · 2015Review
- Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes.Molecular cell · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Dispersed genetic elements, such as retrotransposons and Pol-III-transcribed genes, including tRNA and 5S rRNA, cluster and associate with centromeres in fission yeast through the function of condensin. However, the dynamics of these condensin-mediated genomic associations remains unknown. We have examined the 3D motions of genomic loci including the centromere, telomere, rDNA repeat locus, and the loci carrying Pol-III-transcribed genes or long-terminal repeat (LTR) retrotransposons in live cells at as short as 1.5-second intervals. Treatment with carbendazim (CBZ), a microtubule-destabilizing agent, not only prevents centromeric motion, but also reduces the mobility of the other genomic loci during interphase. Further analyses demonstrate that condensin-mediated associations between centromeres and the genomic loci are clonal, infrequent and transient. However, when associated, centromeres and the genomic loci migrate together in a coordinated fashion. In addition, a condensin mutation that disrupts associations between centromeres and the genomic loci results in a concomitant decrease in the mobility of the loci. Our study suggests that highly mobile centromeres pulled by microtubules in cytoplasm serve as 'genome mobility elements' by facilitating physical relocations of associating genomic regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.