ArticleThe Journal of nutrition2013
Intake of specific nonfermented soy foods may be inversely associated with risk of distal gastric cancer in a Chinese population.
Article in The Journal of nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Intake of Soy, Soy Isoflavones and Soy Protein and Risk of Cancer Incidence and Mortality.Frontiers in nutrition · 2022Pooled it
- The association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies.BMC public health · 2018Pooled it
- Soy food intake and risk of gastric cancer: A dose-response meta-analysis of prospective studies.Medicine · 2017Pooled it
- Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk.Scientific reports · 2017Pooled it
- Soy and isoflavone consumption and risk of gastrointestinal cancer: a systematic review and meta-analysis.European journal of nutrition · 2016Pooled it
- Association between legume consumption and risk of esophageal cancer among Chinese adults: a 17-year prospective cohort study.Cancer causes & control : CCC · 2025Article
- Soybean product consumption decreases risk of gastric cancer: results from the Health Examinees Study.European journal of nutrition · 2023Article
- Phytochemicals for the Prevention and Treatment of Gastric Cancer: Effects and Mechanisms.International journal of molecular sciences · 2020Review
- Perspectives Regarding the Role of Biochanin A in Humans.Frontiers in pharmacology · 2019Review
- Observational
- Article
- Development of quantitative index evaluating anticancer or carcinogenic potential of diet: the anti-cancer food scoring system 1.0.Nutrition research and practice · 2018Article
- Fruit and vegetable consumption, Helicobacter pylori antibodies, and gastric cancer risk: A pooled analysis of prospective studies in China, Japan, and Korea.International journal of cancer · 2017Article
- Dietary Protein Sources and All-Cause and Cause-Specific Mortality: The Golestan Cohort Study in Iran.American journal of preventive medicine · 2017Article
- Different Pathophysiology of Gastritis in East and West? A Western Perspective.Inflammatory intestinal diseases · 2016Review
- Dietary isoflavones and gastric cancer: A brief review of current studies.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Review
- One-carbon metabolism dietary factors and distal gastric cancer risk in chinese women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
Because the association between soy consumption and gastric cancer is inconsistent, we evaluated the putative preventive effect of soy food on gastric cancer risk in the Shanghai Women's and Men's Health Studies, comprising a total of 128,687 participants. Intake of nonfermented soy foods was estimated using 2 validated food-frequency questionnaires. HRs were calculated with 95% CIs for intake amounts of total nonfermented soy food intake, soy protein, and isoflavones as well as individual soy food groups using Cox proportional hazards regression. A total of 493 distal gastric cancer cases were identified by 2010. Although all risk estimates for summary measures of soy food intake above the lowest quartile (quartile 1) were suggestive of a protective effect, no statistically significant associations with risk of distal gastric cancer were found. Among the separate soy food groups, significant reductions in risk of distal gastric cancer by increasing intake of tofu were found in men in quartile 2 (HR: 0.59; 95% CI: 0.40, 0.86), quartile 3 (HR: 0.62; 95% CI: 0.44, 0.88), and quartile 4 (HR: 0.64; 95% CI: 0.42, 0.99), resulting in a significant trend (P-trend = 0.02). Dry bean intake was also inversely associated with decreased risk of gastric cancer, but in postmenopausal women only [quartile 2 (HR: 0.54; 95% CI: 0.30, 0.96); quartile 3 (HR: 0.90; 95% CI: 0.64, 1.27); and quartile 4 (HR: 0.63; 95% CI: 0.43, 0.91)], resulting in a significant trend (P-trend = 0.03). Overall, our study found no statistically significant association between nonfermented soy food intake and distal gastric cancer risk, though the data supported the hypothesis that tofu may protect against distal gastric cancer in men and dry bean consumption may decrease the risk of gastric cancer in postmenopausal women.
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