ArticleCroatian medical journal2013
Prediction of eye color in the Slovenian population using the IrisPlex SNPs.
Article in Croatian medical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 62 citations in OpenAlex.
- Evaluation of the Prediction Potential of the HIrisPlex-S System in a North German Population.Genes · 2026Article
- Genetics of Skin, Hair, and Eye Color in Human Pigmentation Disorders.Annals of human genetics · 2025Review
- Forensic DNA Phenotyping: Examining knowledge and operational view from police officers.Forensic science international. Synergy · 2025Article
- Forensic DNA phenotyping: a review on SNP panels, genotyping techniques, and prediction models.Forensic sciences research · 2025Review
- Exploring Eye, Hair, and Skin Pigmentation in a Spanish Population: Insights from Hirisplex-S Predictions.Genes · 2024Article
- Estimation of genetic variation in vitiligo associated genes: Population genomics perspective.BMC genomic data · 2024Article
- Predictive accuracy of genetic variants for eye color in a Kazakh population using the IrisPlex system.BMC research notes · 2024Article
- The Revolution of Animal Genomics in Forensic Sciences.International journal of molecular sciences · 2023Review
- Article
- A new approach to broaden the range of eye colour identifiable by IrisPlex in DNA phenotyping.Scientific reports · 2022Article
- Prediction of eye and hair pigmentation phenotypes using the HIrisPlex system in a Brazilian admixed population sample.International journal of legal medicine · 2021Article
- Eye color prediction using single nucleotide polymorphisms in Saudi population.Saudi journal of biological sciences · 2019Article
- An overview of the latest developments in facial imaging.Forensic sciences research · 2019Review
- Global skin colour prediction from DNA.Human genetics · 2017Article
- Forensically relevant SNaPshotInternational journal of legal medicine · 2017Review
- Further evidence for population specific differences in the effect of DNA markers and gender on eye colour prediction in forensics.International journal of legal medicine · 2016Article
- Assessment of IrisPlex-based multiplex for eye and skin color prediction with application to a Portuguese population.International journal of legal medicine · 2015Article
- Genetic and phenotypic variability of iris color in Buenos Aires population.Genetics and molecular biologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the accuracy of eye color prediction based on six IrisPlex single nucleotide polymorphisms (SNP) in a Slovenian population sample.
methodsSix IrisPlex predictor SNPs (HERC2 - rs12913832, OCA2 - rs1800407, SLC45A2 - rs16891982 and TYR - rs1393350, SLC24A4 - rs12896399, and IRF4 - rs12203592) of 105 individuals were analyzed using single base extension approach and SNaPshot chemistry. The IrisPlex multinomial regression prediction model was used to infer eye color probabilities. The accuracy of the IrisPlex was assessed through the calculation of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and the area under the receiver characteristic operating curves (AUC).
resultsBlue eye color was observed in 44.7%, brown in 29.6%, and intermediate in 25.7% participants. Prediction accuracy expressed by the AUC was 0.966 for blue, 0.913 for brown, and 0.796 for intermediate eye color. Sensitivity was 93.6% for blue, 58.1% for brown, and 0% for intermediate eye color. Specificity was 93.1% for blue, 89.2% for brown, and 100% for intermediate eye color. PPV was 91.7% for blue and 69.2% for brown color. NPV was 94.7% for blue and 83.5% for brown eye color. These values indicate prediction accuracy comparable to that established in other studies.
conclusionBlue and brown eye color can be reliably predicted from DNA samples using only six polymorphisms, while intermediate eye color defies prediction, indicating that more research is needed to genetically predict the whole variation of eye color in humans.
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