ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
A systems-based dissection of retinal inputs to the zebrafish tectum reveals different rules for different functional classes during development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Neural Circuit Mechanisms Involved in Animals' Detection of and Response to Visual Threats.Neuroscience bulletin · 2023Review
- Valproic acid affects neurogenesis during early optic tectum development in zebrafish.Biology open · 2023Article
- From perception to behavior: The neural circuits underlying prey hunting in larval zebrafish.Frontiers in neural circuits · 2023Review
- Single-Cell RNA Sequencing Characterizes the Molecular Heterogeneity of the Larval Zebrafish Optic Tectum.Frontiers in molecular neuroscience · 2022Article
- Colored visual stimuli evoke spectrally tuned neuronal responses across the central nervous system of zebrafish larvae.BMC biology · 2020Article
- Selective processing of all rotational and translational optic flow directions in the zebrafish pretectum and tectum.BMC biology · 2019Article
- Probabilistic Encoding Models for Multivariate Neural Data.Frontiers in neural circuits · 2019Review
- In vivo two-photon imaging of the embryonic cortex reveals spontaneous ketamine-sensitive calcium activity.Scientific reports · 2018Article
- Visual Experience Facilitates BDNF-Dependent Adaptive Recruitment of New Neurons in the Postembryonic Optic Tectum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Orientation-Selective Retinal Circuits in Vertebrates.Frontiers in neural circuits · 2018Review
- Retinal origin of direction selectivity in the superior colliculus.Nature neuroscience · 2017Article
- Characterisation of sensitivity and orientation tuning for visually responsive ensembles in the zebrafish tectum.Scientific reports · 2016Article
- Neural Mechanisms Generating Orientation Selectivity in the Retina.Current biology : CB · 2016Article
- A crystal-clear zebrafish for in vivo imaging.Scientific reports · 2016Article
- Article
- Adaptation-induced modification of motion selectivity tuning in visual tectal neurons of adult zebrafish.Journal of neurophysiology · 2015Article
- Neurons in the most superficial lamina of the mouse superior colliculus are highly selective for stimulus direction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Retinal ganglion cell maps in the brain: implications for visual processing.Current opinion in neurobiology · 2014Review
- Brain on the stage - spotlight on nervous system development in zebrafish: EMBO practical course, KIT, Sept. 2013.Neural development · 2013Article
- Teneurin-3 specifies morphological and functional connectivity of retinal ganglion cells in the vertebrate visual system.Cell reports · 2013Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
We have examined the form, diversity, and organization of three functional classes of retinal inputs to the zebrafish optic tectum during development. Our systems-based approach was to analyze data from populations of retinal ganglion cells labeled with a presynaptic targeted calcium indicator, synaptophysin GCaMP3 (SyGCaMP3). Collectively, our findings provide an insight as to the degree of visual encoding during retino-tectal development and how it dynamically evolves from a nascent and noisy presynaptic neural-scape to an increasingly complex and refined representation. We report five key features: (1) direction-selective inputs are developmentally invariant; (2) orientation-selective inputs exhibit highly dynamic properties over the same period, with changes in their functional characteristics and spatial organization; (3) inputs defined as anisotropic are an early dominant functional class, with heterogeneous response profiles, which progressively diminish in incidence and spatial extent; (4) dark rearing selectively affects the orientation-selective responses: both functional characteristics and relative spatial distributions; and (5) orientation-selective inputs exhibit four subtypes, two more than previously identified in any species. Our approach was to label RGC axon terminals with an indicator of activity and quantitatively characterize coherent response properties to different visual stimuli. Its application in the zebrafish, given its small size and the accessibility of the tectum, has enabled a quick yet robust assessment of multiple functional populations of responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.