ArticleProceedings. Biological sciences2013
Dynamics of mitochondrial inheritance in the evolution of binary mating types and two sexes.
Article in Proceedings. Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- Optimal Organelle Inheritance Strategies Under Different Changing Environments and Mutational Pressures.Genome biology and evolution · 2026Article
- Evidence for Paternal Mitochondrial DNA Leakage in Diploid Hybrid Fish Lineages.Animals : an open access journal from MDPI · 2026Article
- Cellular and environmental dynamics influence species-specific extents of organelle gene retention.Proceedings. Biological sciences · 2023Article
- The need for high-quality oocyte mitochondria at extreme ploidy dictates mammalian germline development.eLife · 2021Article
- Review
- Invasion and Extinction Dynamics of Mating Types Under Facultative Sexual Reproduction.Genetics · 2019Article
- Evolution of asymmetric gamete signaling and suppressed recombination at the mating type locus.eLife · 2019Article
- Assessing the fitness consequences of mitonuclear interactions in natural populations.Biological reviews of the Cambridge Philosophical Society · 2019Article
- Sex and Mitonuclear Adaptation in ExperimentalGenetics · 2019Article
- Selfish genetic elements.PLoS genetics · 2018Review
- Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance.Current biology : CB · 2018Review
- Article
- Sexual conflict explains the extraordinary diversity of mechanisms regulating mitochondrial inheritance.BMC biology · 2017Article
- Uniparental Inheritance Promotes Adaptive Evolution in Cytoplasmic Genomes.Molecular biology and evolution · 2017Article
- Selection for Mitochondrial Quality Drives Evolution of the Germline.PLoS biology · 2016Article
- Gamete signalling underlies the evolution of mating types and their number.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- What do isogamous organisms teach us about sex and the two sexes?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- What can we infer about the origin of sex in early eukaryotes?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Mitochondria, the Cell Cycle, and the Origin of Sex via a Syncytial Eukaryote Common Ancestor.Genome biology and evolution · 2016Article
- Conflict and cooperation in eukaryogenesis: implications for the timing of endosymbiosis and the evolution of sex.Journal of the Royal Society, Interface · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The uniparental inheritance (UPI) of mitochondria is thought to explain the evolution of two mating types or even true sexes with anisogametes. However, the exact role of UPI is not clearly understood. Here, we develop a new model, which considers the spread of UPI mutants within a biparental inheritance (BPI) population. Our model explicitly considers mitochondrial mutation and selection in parallel with the spread of UPI mutants and self-incompatible mating types. In line with earlier work, we find that UPI improves fitness under mitochondrial mutation accumulation, selfish conflict and mitonuclear coadaptation. However, we find that as UPI increases in the population its relative fitness advantage diminishes in a frequency-dependent manner. The fitness benefits of UPI 'leak' into the biparentally reproducing part of the population through successive matings, limiting the spread of UPI. Critically, while this process favours some degree of UPI, it neither leads to the establishment of linked mating types nor the collapse of multiple mating types to two. Only when two mating types exist beforehand can associated UPI mutants spread to fixation under the pressure of high mitochondrial mutation rate, large mitochondrial population size and selfish mutants. Variation in these parameters could account for the range of UPI actually observed in nature, from strict UPI in some Chlamydomonas species to BPI in yeast. We conclude that UPI of mitochondria alone is unlikely to have driven the evolution of two mating types in unicellular eukaryotes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.