ArticleGenome biology and evolution2013
Phylogenomic data support a seventh order of Methylotrophic methanogens and provide insights into the evolution of Methanogenesis.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
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Who cites it
107 citing papers in PubMed, 277 citations in OpenAlex.
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- Reinforcement of Microbial Electrolytic Cells by Redox Mediators Modified Carbon Felt Electrodes: Electrochemistry and Microbial Dynamics.Applied biochemistry and biotechnology · 2025Article
- Methane cycling microorganisms drive seasonal variation of methane emission in mangrove ecosystems.Environmental microbiome · 2025Article
- Pyrrolysine Aminoacyl-tRNA Synthetase as a Tool for Expanding the Genetic Code.International journal of molecular sciences · 2025Review
- Shaken not stirred - effect of different mixing modes during the cultivation of methanogenic pure cultures.Current research in microbial sciences · 2025Article
- Microbial and chemical predictors of methane release from a stratified thermokarst permafrost hotspot.Frontiers in microbiology · 2025Article
- Co-evolution of early Earth environments and microbial life.Nature reviews. Microbiology · 2024Review
- Unraveling the phylogenomic diversity of Methanomassiliicoccales and implications for mitigating ruminant methane emissions.Genome biology · 2024Article
- Methylotrophy in the Mire: direct and indirect routes for methane production in thawing permafrost.mSystems · 2024Article
- Human associated Archaea: a neglected microbiome worth investigating.World journal of microbiology & biotechnology · 2024Review
- Hydrogen-independent COISME communications · 2024Article
- Article
- A compendium of viruses from methanogenic archaea reveals their diversity and adaptations to the gut environment.Nature microbiology · 2023Article
- Methylotrophic methanogens and bacteria synergistically demethylate dimethylarsenate in paddy soil and alleviate rice straighthead disease.The ISME journal · 2023Article
- Organic matter lability modifies the vertical structure of methane-related microbial communities in lake sediments.Microbiology spectrum · 2023Article
- The methanogen core and pangenome: conservation and variability across biology's growth temperature extremes.DNA research : an international journal for rapid publication of reports on genes and genomes · 2023Article
- Evolving understanding of rumen methanogen ecophysiology.Frontiers in microbiology · 2023Review
- Factors shaping the abundance and diversity of the gut archaeome across the animal kingdom.Nature communications · 2022Article
47 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence from sequence data from various environments, including the human gut, suggests the existence of a previously unknown putative seventh order of methanogens. The first genomic data from members of this lineage, Methanomassiliicoccus luminyensis and "Candidatus Methanomethylophilus alvus," provide insights into its evolutionary history and metabolic features. Phylogenetic analysis of ribosomal proteins robustly indicates a monophyletic group independent of any previously known methanogenic order, which shares ancestry with the Marine Benthic Group D, the Marine Group II, the DHVE2 group, and the Thermoplasmatales. This phylogenetic position, along with the analysis of enzymes involved in core methanogenesis, strengthens a single ancient origin of methanogenesis in the Euryarchaeota and indicates further multiple independent losses of this metabolism in nonmethanogenic lineages than previously suggested. Genomic analysis revealed an unprecedented loss of the genes coding for the first six steps of methanogenesis from H₂/CO₂ and the oxidative part of methylotrophic methanogenesis, consistent with the fact that M. luminyensis and "Ca. M. alvus" are obligate H₂-dependent methylotrophic methanogens. Genomic data also suggest that these methanogens may use a large panel of methylated compounds. Phylogenetic analysis including homologs retrieved from environmental samples indicates that methylotrophic methanogenesis (regardless of dependency on H₂) is not restricted to gut representatives but may be an ancestral characteristic of the whole order, and possibly also of ancient origin in the Euryarchaeota. 16S rRNA and McrA trees show that this new order of methanogens is very diverse and occupies environments highly relevant for methane production, therefore representing a key lineage to fully understand the diversity and evolution of methanogenesis.
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