ArticleJournal of clinical microbiology2013
Splitting of a prevalent Mycobacterium bovis spoligotype by variable-number tandem-repeat typing reveals high heterogeneity in an evolving clonal group.
Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- SITVITBovis-a publicly available database and mapping tool to get an improved overview of animal and human cases caused by Mycobacterium bovis.Database : the journal of biological databases and curation · 2022Article
- Article
- Whole-Genome SNP Analysis Identifies PutativeMicroorganisms · 2021Article
- Spoligotype-specific risk of finding lesions in tissues from cattle infected by Mycobacterium bovis.BMC veterinary research · 2021Article
- Single-nucleotide polymorphism-based epidemiological analysis of KoreanJournal of veterinary science · 2021Article
- Performance and Agreement Between WGS Variant Calling Pipelines Used for Bovine Tuberculosis Control: Toward International Standardization.Frontiers in veterinary science · 2021Article
- Long-term molecular surveillance provides clues on a cattle origin for Mycobacterium bovis in Portugal.Scientific reports · 2020Article
- Genotype diversity and distribution of Mycobacterium bovis from livestock in a small, high-risk area in northeastern Sicily, Italy.PLoS neglected tropical diseases · 2019Article
- Accurate Phylogenetic Relationships AmongFrontiers in microbiology · 2019Article
- Complete Genome Sequencing ofFrontiers in microbiology · 2017Article
- Article
- Proposal of a Screening MIRU-VNTR Panel for the Preliminary Genotyping of Mycobacterium bovis in Mexico.BioMed research international · 2015Article
- Genetic evolution of Mycobacterium bovis causing tuberculosis in livestock and wildlife in France since 1978.PloS one · 2015Article
- Spatial dynamics of bovine tuberculosis in the Autonomous Community of Madrid, Spain (2010-2012).PloS one · 2014Article
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Authors and funding
12 authors.
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Abstract
Mycobacterium bovis populations in countries with persistent bovine tuberculosis usually show a prevalent spoligotype with a wide geographical distribution. This study applied mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) typing to a random panel of 115 M. bovis isolates that are representative of the most frequent spoligotype in the Iberian Peninsula, SB0121. VNTR typing targeted nine loci: ETR-A (alias VNTR2165), ETR-B (VNTR2461), ETR-D (MIRU4, VNTR580), ETR-E (MIRU31, VNTR3192), MIRU26 (VNTR2996), QUB11a (VNTR2163a), QUB11b (VNTR2163b), QUB26 (VNTR4052), and QUB3232 (VNTR3232). We found a high degree of diversity among the studied isolates (discriminatory index [D] = 0.9856), which were split into 65 different MIRU-VNTR types. An alternative short-format MIRU-VNTR typing targeting only the four loci with the highest variability values was found to offer an equivalent discriminatory index. Minimum spanning trees using the MIRU-VNTR data showed the hypothetical evolution of an apparent clonal group. MIRU-VNTR analysis was also applied to the isolates of 176 animals from 15 farms infected by M. bovis SB0121; in 10 farms, the analysis revealed the coexistence of two to five different MIRU types differing in one to six loci, which highlights the frequency of undetected heterogeneity.
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