Evidence map›Paper›PMID 23985720›Full record

ArticleTransplantation2013

Regulation of molecular pathways in ischemia-reperfusion injury after liver transplantation.

Ricardo C Gehrau, Valeria R Mas, Catherine I Dumur, Danielle E Ladie, Jihee L Suh, Samuel Luebbert, Daniel G Maluf

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Banff 2019 Meeting Report: Molecular diagnostics in solid organ transplantation-Consensus for the Banff Human Organ Transplant (B-HOT) gene panel and open source multicenter validation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  3. Article
  4. Article
  5. Novel Targets for Treating Ischemia-Reperfusion Injury in the Liver.International journal of molecular sciences · 2018
    Review
  6. MicroRNA-146b-5p Identified in Porcine Liver Donation Model is Associated with Early Allograft Dysfunction in Human Liver Transplantation.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Article
  7. Article
  8. Article
  9. CD47 blockade reduces ischemia/reperfusion injury and improves survival in a rat liver transplantation model.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ricardo C Gehrau1 Transplant Division, Department of Surgery, University of Virginia, Charlottesville, VA. 2 Department of Pathology, Virginia Commonwealth University, Richmond, VA. 3 Address correspondence to Daniel G. Maluf, M.D., Liver Transplant Program, Transplant Division, Department of Surgery, University of Virginia, 1300 Jefferson Park Avenue, Barringer 5, Room 5417, Charlottesville, VA.
Valeria R Mas
Catherine I Dumur
Danielle E Ladie
Jihee L Suh
Samuel Luebbert
Daniel G Maluf

Funding

Molecular pathways leading to chronic graft dysfunctionR01DK080074 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI MAS, VALERIA RAQUEL · 2008 to 2012
$1.8M
NIDDK NIH HHS R01 DK080074NIDDK NIH HHS R01DK080074
6 · The paper itself

Abstract

backgroundIschemia-reperfusion (I/R) injury is a multifactorial phenomenon that occurs during the transplant event and frequently compromises early graft function after liver transplantation (LT). Current comprehension of molecular mechanisms and regulation processes of I/R injury lacks clarity. MicroRNA (miRNA) regulation results critical in several biological processes.

methodsThis study evaluated gene expression and miRNA expression profiles using microarrays in 34 graft biopsies collected at preimplantation (L1) and at 90 min postreperfusion (L2) from consecutives deceased-donor LT recipients. miRNA profiles were first analyzed. Data integration analysis (gene expression/miRNA expression) aimed to identify potential target genes for each identified miRNA from the L1/L2 differential gene expression profile.

resultsPairwise comparison analyses identified 40 miRNAs and 3168 significantly differentially expressed genes at postreperfusion time compared with preimplantation time. Pathway analysis of miRNAs associated these profiles with antiapoptosis, inhibition of cellular proliferation, and proinflammatory processes. Target analysis identified an miRNA-associated molecular profile of 2172 genes involved in cellular growth and proliferation modulation by cell cycle regulation, cell death and survival, and proinflammatory and anti-inflammatory processes. miRNA-independent genes involved proinflammatory molecules.

conclusionWe identified a miRNA profile involved in posttranscriptional regulatory mechanisms in I/R injury post-LT. A better understanding of these molecular processes involved in I/R may contribute to develop new strategies to minimize graft injury.

Indexed as

Gene Expression RegulationLiver TransplantationAdultAgedBiopsyFemaleFollow-Up StudiesGene Expression ProfilingGraft RejectionHumansMaleMicroRNAsMiddle AgedPostoperative PeriodReperfusion InjuryTranscription, GeneticMicroRNAs

Identifiers

PMID23985720
PMCPMC4377108

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.