ArticleEndocrine connections2013
Human infertility: are endocrine disruptors to blame?
Article in Endocrine connections, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 123 citations in OpenAlex.
- Trial
- Implications of Endocrine-Disrupting Chemicals for Human Health and Effective Methods for Prevention and Reduction.Toxics · 2026Review
- Exploratory assessment of preconception phthalate exposure on pregnancy and offspring health outcomes in mice.Journal of the Endocrine Society · 2026Article
- Article
- Empowering Student Pharmacists to Counsel Patients on Endocrine Disrupting Chemicals through Interactive Role-Play.Pharmacy (Basel, Switzerland) · 2024Article
- Perinatal Outcomes of Monochorionic Twin Pregnancies Conceived Naturally Versus through Assisted Reproductive Techniques.Journal of clinical medicine · 2023Article
- Article
- The role of endocrine disruptors in female infertility.Molecular biology reports · 2023Review
- Cocaine Effects on Reproductive Behavior and Fertility: An Overview.Veterinary sciences · 2023Review
- Endocrine disrupting chemicals and male fertility: from physiological to molecular effects.Frontiers in public health · 2023Review
- The role of oxidative stress in ovarian aging: a review.Journal of ovarian research · 2022Review
- Effects of Tartrazine on Some Sexual Maturation Parameters in Immature Female Wistar Rats.International journal of environmental research and public health · 2022Article
- Pesticides and Male Fertility: A Dangerous Crosstalk.Metabolites · 2021Review
- Review
- In Vitro and Vivo Identification, Metabolism and Action of Xenoestrogens: An Overview.International journal of molecular sciences · 2021Review
- Environmentally relevant mixtures of phthalates and phthalate metabolites differentially alter the cell cycle and apoptosis in mouse neonatal ovaries†.Biology of reproduction · 2021Article
- Developmental, behavioral and endocrine alterations in male rats at early and late postnatal life following in utero exposure to low dose di-Toxicological research · 2021Article
- Environment, Lifestyle, and Female Infertility.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Organopesticides and fertility: where does the link lead to?Environmental science and pollution research international · 2021Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over recent decades, epidemiological studies have been reporting worrisome trends in the incidence of human infertility rates. Extensive detection of industrial chemicals in human serum, seminal plasma and follicular fluid has led the scientific community to hypothesise that these compounds may disrupt hormonal homoeostasis, leading to a vast array of physiological impairments. Numerous synthetic and natural substances have endocrine-disruptive effects, acting through several mechanisms. The main route of exposure to these chemicals is the ingestion of contaminated food and water. They may disturb intrauterine development, resulting in irreversible effects and may also induce transgenerational effects. This review aims to summarise the major scientific developments on the topic of human infertility associated with exposure to endocrine disruptors (EDs), integrating epidemiological and experimental evidence. Current data suggest that environmental levels of EDs may affect the development and functioning of the reproductive system in both sexes, particularly in foetuses, causing developmental and reproductive disorders, including infertility. EDs may be blamed for the rising incidence of human reproductive disorders. This constitutes a serious public health issue that should not be overlooked. The exposure of pregnant women and infants to EDs is of great concern. Therefore, precautionary avoidance of exposure to EDs is a prudent attitude in order to protect humans and wildlife from permanent harmful effects on fertility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.