ArticleMolecular biology of the cell2013
Wounded cells drive rapid epidermal repair in the early Drosophila embryo.
Article in Molecular biology of the cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 75 citations in OpenAlex.
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- Reactive oxygen species counteract zebrafish wound contraction and promote wound healing.Biophysical journal · 2025Article
- Physical Forces in Regeneration of Cells and Tissues.Cold Spring Harbor perspectives in biology · 2025Review
- Microdifferential Pressure Measurement Device for Cellular Microenvironments.Bioengineering (Basel, Switzerland) · 2024Article
- Mechanical state transitions in the regulation of tissue form and function.Nature reviews. Molecular cell biology · 2024Review
- Crumbs complex-directed apical membrane dynamics in epithelial cell ingression.The Journal of cell biology · 2022Article
- The role of tissue maturity and mechanical state in controlling cell extrusion.Current opinion in genetics & development · 2022Review
- The endocycle restores tissue tension in the Drosophila abdomen post wound repair.Cell reports · 2021Article
- Collective migration during a gap closure in a two-dimensional haptotactic model.Scientific reports · 2021Article
- Arp2/3-dependent mechanical control of morphogenetic robustness in an inherently challenging environment.Developmental cell · 2021Article
- Src kinases relax adherens junctions between the neighbors of apoptotic cells to permit apical extrusion.Molecular biology of the cell · 2020Article
- The pulse of morphogenesis: actomyosin dynamics and regulation in epithelia.Development (Cambridge, England) · 2020Review
- Collagen, stiffness, and adhesion: the evolutionary basis of vertebrate mechanobiology.Molecular biology of the cell · 2020Review
- Measuring mechanical stress in living tissues.Nature reviews. Physics · 2020Article
- Cell-free fat extract accelerates diabetic wound healing in db/db mice.American journal of translational research · 2020Article
- Actin and myosin dynamics are independent duringMolecular biology of the cell · 2019Article
- Structural Redundancy in Supracellular Actomyosin Networks Enables Robust Tissue Folding.Developmental cell · 2019Article
- The Crk adapter protein is essential forMolecular biology of the cell · 2019Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelial tissues are protective barriers that display a remarkable ability to repair wounds. Wound repair is often associated with an accumulation of actin and nonmuscle myosin II around the wound, forming a purse string. The role of actomyosin networks in generating mechanical force during wound repair is not well understood. Here we investigate the mechanisms of force generation during wound repair in the epidermis of early and late Drosophila embryos. We find that wound closure is faster in early embryos, where, in addition to a purse string around the wound, actomyosin networks at the medial cortex of the wounded cells contribute to rapid wound repair. Laser ablation demonstrates that both medial and purse-string actomyosin networks generate contractile force. Quantitative analysis of protein localization dynamics during wound closure indicates that the rapid contraction of medial actomyosin structures during wound repair in early embryos involves disassembly of the actomyosin network. By contrast, actomyosin purse strings in late embryos contract more slowly in a mechanism that involves network condensation. We propose that the combined action of two force-generating structures--a medial actomyosin network and an actomyosin purse string--contributes to the increased efficiency of wound repair in the early embryo.
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