ArticleMolecular biology of the cell2013
Dissociation of the H3K36 demethylase Rph1 from chromatin mediates derepression of environmental stress-response genes under genotoxic stress in Saccharomyces cerevisiae.
Article in Molecular biology of the cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- The evening complex component ELF3 recruits H3K4me3 demethylases to repress PHYTOCHROME INTERACTING FACTOR4 and 5 in Arabidopsis.The Plant cell · 2024Article
- Redox signaling, mitochondrial metabolism, epigenetics and redox active phytochemicals.Free radical biology & medicine · 2022Review
- A phosphatase-centric mechanism drives stress signaling response.EMBO reports · 2021Article
- Ready, SET, Go: Post-translational regulation of the histone lysine methylation network in budding yeast.The Journal of biological chemistry · 2021Review
- Rph1 coordinates transcription of ribosomal protein genes and ribosomal RNAs to control cell growth under nutrient stress conditions.Nucleic acids research · 2020Article
- The Histone H3K4 Demethylase JMJ16 Represses Leaf Senescence in Arabidopsis.The Plant cell · 2019Article
- Transcriptional and post-transcriptional regulation of autophagy in the yeastThe Journal of biological chemistry · 2018Review
- Gcn5-mediated Rph1 acetylation regulates its autophagic degradation under DNA damage stress.Nucleic acids research · 2017Article
- An overview of macroautophagy in yeast.Journal of molecular biology · 2016Review
- Article
- KdmA, a histone H3 demethylase with bipartite function, differentially regulates primary and secondary metabolism in Aspergillus nidulans.Molecular microbiology · 2015Article
- Immediate chromatin immunoprecipitation and on-bead quantitative PCR analysis: a versatile and rapid ChIP procedure.Nucleic acids research · 2015Article
- Rph1/KDM4 mediates nutrient-limitation signaling that leads to the transcriptional induction of autophagy.Current biology : CB · 2015Article
- The Histone Acetyltransferase Gcn5 Regulates ncRNA-ICR1 and FLO11 Expression during Pseudohyphal Development in Saccharomyces cerevisiae.BioMed research international · 2015Article
- Histone methylation and aging: lessons learned from model systems.Biochimica et biophysica acta · 2014Review
- The histone demethylase activity of Rph1 is not essential for its role in the transcriptional response to nutrient signaling.PloS one · 2014Article
- Post-translational modification analysis of Saccharomyces cerevisiae histone methylation enzymes reveals phosphorylation sites of regulatory potential.The Journal of biological chemistryArticle
- Transcriptional Regulation in Roots by Bacteria With 1-Aminocyclopropane-1-Carboxylate Deaminase Enzymes for Drought Tolerance and Post-Stress Recovery.Physiologia plantarumArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells respond to environmental signals by altering gene expression through transcription factors. Rph1 is a histone demethylase containing a Jumonji C (JmjC) domain and belongs to the C(2)H(2) zinc-finger protein family. Here we investigate the regulatory network of Rph1 in yeast by expression microarray analysis. More than 75% of Rph1-regulated genes showed increased expression in the rph1-deletion mutant, suggesting that Rph1 is mainly a transcriptional repressor. The binding motif 5'-CCCCTWA-3', which resembles the stress response element, is overrepresented in the promoters of Rph1-repressed genes. A significant proportion of Rph1-regulated genes respond to DNA damage and environmental stress. Rph1 is a labile protein, and Rad53 negatively modulates Rph1 protein level. We find that the JmjN domain is important in maintaining protein stability and the repressive effect of Rph1. Rph1 is directly associated with the promoter region of targeted genes and dissociated from chromatin before transcriptional derepression on DNA damage and oxidative stress. Of interest, the master stress-activated regulator Msn2 also regulates a subset of Rph1-repressed genes under oxidative stress. Our findings confirm the regulatory role of Rph1 as a transcriptional repressor and reveal that Rph1 might be a regulatory node connecting different signaling pathways responding to environmental stresses.
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