ArticleItalian journal of pediatrics2013
Antiepileptic drugs and breastfeeding.
Article in Italian journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Breastfeeding initiation and continuation among women on medicines: a systematic review and meta-analysis.BMJ open · 2026Pooled it
- Pharmacokinetics of Atogepant in Healthy Lactating Female Participants: Results from a Phase 1 Lactation Study.Neurology and therapy · 2025Article
- Toxic epidermal necrolysis following lamotrigine replacement therapy in a woman planning pregnancy: a case report and literature review.BMC women's health · 2025Review
- The Impact of Substance Use Disorder and Drug Transfer into Breast Milk: Implications for Maternal and Infant Health.Pharmaceutics · 2025Review
- Article
- Management of anti-seizure medications in lactating women with epilepsy.Frontiers in neurology · 2022Review
- Treatment and care of women with epilepsy before, during, and after pregnancy: a practical guide.Therapeutic advances in neurological disorders · 2022Review
- Outcomes for 298 breastfed neonates whose mothers received ketamine and diazepam for postpartum tubal ligation in a resource-limited setting.BMC pregnancy and childbirth · 2021Article
- Antiseizure drugs for women with epilepsy: Before, during, and after pregnancy.Canadian family physician Medecin de famille canadien · 2020Article
- Biological barriers, and the influence of protein binding on the passage of drugs across them.Molecular biology reports · 2020Review
- Antiseizure medications in critical care: an update.Current opinion in critical care · 2019Review
- Psychoactive drug exposure during breastfeeding: a critical need for preclinical behavioral testing.Psychopharmacology · 2018Review
- Contraception, pregnancy, and peripartum experiences among women with epilepsy in Bhutan.Epilepsy research · 2017Article
- In Utero Oxcarbazepine Exposure and Neonatal Abstinence Syndrome: Case Report and Brief Review of the Literature.Pharmacotherapy · 2017Review
- Neonatal Adaptation Issues After Maternal Exposure to Prescription Drugs: Withdrawal Syndromes and Residual Pharmacological Effects.Drug safety · 2016Review
- [Epilepsy and Pregnancy].Der Nervenarzt · 2016Review
- Continuous Ilioinguinal-iliohypogastric Nerve Block for Groin Pain in a Breast-feeding Patient after Cesarean Delivery.The Korean journal of pain · 2016Article
- Management of epilepsy during pregnancy: evidence-based strategies.Future neurology · 2015Article
- Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database.European journal of clinical pharmacology · 2014Article
- Breastfeeding and migraine drugs.European journal of clinical pharmacology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis review provides a synopsis for clinicians on the use of antiepileptic drugs (AEDs) in the breastfeeding mother.
methodsFor each AED, we collected all retrievable data from Hale's "Medications and Mother Milk" (2012), from the LactMed database (2013) of the National Library of Medicine, and from a MedLine Search of relevant studies in the past 10 years.
resultsOlder AEDs, such as carbamazepine, valproic acid, phenytoin, phenobarbital, primidone are considered to have a good level of safety during lactation, due to the long term clinical experience and the consequent amount of available data from the scientific literature. On the contrary, fewer data are available on the use of new AEDs. Therefore, gabapentin, lamotrigine, oxcarbazepine, vigabatrin, tiagabine, pregabalin, leviracetam and topiramate are compatible with breastfeeding with a less documented safety profile. Ethosuximide, zonisamide and the continue use of clonazepam and diazepam are contraindicated during breastfeeding.
conclusionsAlthough the current available advice on the use of AEDs during breastfeeding, given by different accredited sources, present some contradictions, most AEDs can be considered safe according to our review.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.