Evidence map›Paper›PMID 23985142›Full record

ArticleJournal of the National Cancer Institute2013

Alcohol intake between menarche and first pregnancy: a prospective study of breast cancer risk.

Ying Liu, Graham A Colditz, Bernard Rosner, Catherine S Berkey, Laura C Collins, Stuart J Schnitt, James L Connolly, Wendy Y Chen, Walter C Willett, Rulla M Tamimi

Abstract read
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In one paragraph

Article in Journal of the National Cancer Institute, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  4. Bioscience reports · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ying LiuAffiliations of authors: Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO (YL, GAC); Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO (GAC); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (BR, CSB, WYC, RMT); Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (LCC, SJS, JLC); Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA (WCW).
Graham A Colditz
Bernard Rosner
Catherine S Berkey
Laura C Collins
Stuart J Schnitt
James L Connolly
Wendy Y Chen
Walter C Willett
Rulla M Tamimi

Funding

Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
BENIGN BREAST DISEASE &RISK OF BREAST CANCERR01CA046475 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TAMIMI, RULLA M · 1987 to 2009
$3.1M
NCI NIH HHS R01 CA046475NCI NIH HHS R01 CA050385
6 · The paper itself

Abstract

backgroundAdult alcohol consumption during the previous year is related to breast cancer risk. Breast tissue is particularly susceptible to carcinogens between menarche and first full-term pregnancy. No study has characterized the contribution of alcohol consumption during this interval to risks of proliferative benign breast disease (BBD) and breast cancer.

methodsWe used data from 91,005 parous women in the Nurses' Health Study II who had no cancer history, completed questions on early alcohol consumption in 1989, and were followed through June 30, 2009, to analyze breast cancer risk. A subset of 60,093 women who had no history of BBD or cancer in 1991 and were followed through June 30, 2001, were included in the analysis of proliferative BBD. Relative risks (RRs) were estimated using Cox proportional hazard regression.

resultsWe identified 1609 breast cancer cases and 970 proliferative BBD cases confirmed by central histology review. Alcohol consumption between menarche and first pregnancy, adjusted for drinking after first pregnancy, was associated with risks of breast cancer (RR = 1.11 per 10 g/day intake; 95% confidence interval [CI] = 1.00 to 1.23) and proliferative BBD (RR = 1.16 per 10 g/day intake; 95% CI = 1.02 to 1.32). Drinking after first pregnancy had a similar risk for breast cancer (RR = 1.09 per 10 g/day intake; 95% CI = 0.96 to 1.23) but not for BBD. The association between drinking before first pregnancy and breast neoplasia appeared to be stronger with longer menarche to first pregnancy intervals.

conclusionsAlcohol consumption before first pregnancy was consistently associated with increased risks of proliferative BBD and breast cancer.

Indexed as

MenarcheAdolescentAdultAgedAge DistributionAlcohol DrinkingBreast NeoplasmsEstrogen Replacement TherapyFemaleFibrocystic Breast DiseaseFollow-Up StudiesHumansIncidenceMiddle AgedNursesOdds Ratio

Identifiers

PMID23985142
PMCPMC3797023

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.