Evidence map›Paper›PMID 23985135›Full record

Trial reportCerebral cortex (New York, N.Y. : 1991)2015

Neural mechanisms of brain plasticity with complex cognitive training in healthy seniors.

Sandra B Chapman, Sina Aslan, Jeffrey S Spence, John J Hart, Elizabeth K Bartz, Nyaz Didehbani, Molly W Keebler, Claire M Gardner, Jeremy F Strain, Laura F DeFina and 1 more

8 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 145 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed, 19 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02808676 naterminatednot on this mapstarted 2016, after this paper: background citation

SYNchronizing Exercises, Remedies in GaIt and Cognition (SYNERGIC): A Randomized Controlled Double Blind Trial

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2016 to 2020Enrolled175ConditionsMild Cognitive ImpairmentArmsVitamin D3, Exercises (E), Cognitive Training (CT), placebo D3, control cognitive training
NCT02920632 nacompletednot on this mapstarted 2017, after this paper: background citation

COGTIPS (COGnitive Training In Parkinson Study): The Effect of Online Cognitive Training on Cognition and Brain Networks in Parkinson's Disease

TypeinterventionalSponsorAmsterdam UMC, location VUmcRan2017 to 2021Enrolled167ConditionsParkinson Disease, Impaired Cognition, Alteration in CognitionArmsOnline cognitive training 1, Online cognitive training 2
NCT04869111 narecruitingnot on this mapstarted 2020, after this paper: background citation

The BrainHealth Project, a Longitudinal Study in Generally Healthy Adults

TypeinterventionalSponsorThe University of Texas at DallasRan2020 to 2038Enrolled100,000ConditionsHealthyArmsBrainHealth App-Based Program
NCT05163626 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

Combined Aerobic Exercise and Cognitive Training for Alzheimer's Disease Prevention in At-Risk Seniors Estimated by An Exosomal Synaptic Protein Model: Cognition and Exosomal Synaptic Proteins Effects

TypeinterventionalSponsorXuanwu Hospital, BeijingRan2024 to 2034Enrolled200ConditionsAlzheimer DiseaseArmsCombined aerobic exercise and cognitive training program
NCT05444231 nacompletednot on this mapstarted 2023, after this paper: background citation

Breaking Through the Brain Fog: An Online RCT for Breast Cancer Survivors

TypeinterventionalSponsorThe University of Texas at DallasRan2023 to 2025Enrolled193ConditionsBreast Cancer FemaleArmsBrain Training A, Brain Training B, Brain Training C
NCT06598163 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of a Digital Health App Five Lives MED to Improve Cognitive Function in Patients With Mild Cognitive Impairment: a Randomised Controlled Trial

TypeinterventionalSponsorSharpTxRan2025 to 2026Enrolled170ConditionsMild Cognitive ImpairmentArmsFive Lives MED
NCT06724887 narecruitingnot on this mapstarted 2025, after this paper: background citation

Brain Health on College Campuses

TypeinterventionalSponsorThe University of Texas at DallasRan2025 to 2027Enrolled1,000ConditionsHealth Behavior, Life Style, HealthyArmsBrain Health Strategy Training and Education
NCT07605130 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2×2 Randomized Controlled Trial

TypeinterventionalSponsorPeking Union Medical College HospitalRan2026 to 2029Enrolled420ConditionsIntracranial Arteriosclerosis, Cognitive ImpairmentArmsRosuvastatin, Ezetimibe, Recaticimab, Digital Cognitive Training, Active Control
3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 19 syntheses or guidelines pooled it, 266 citations in OpenAlex.

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  8. Effects of cognitive rehabilitation in Parkinson disease: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
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  16. Variability of physiological brain perfusion in healthy subjects - A systematic review of modifiers. Considerations for multi-center ASL studies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
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85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Sandra B ChapmanCenter for BrainHealth, The University of Texas at Dallas, Dallas, TX 75235, USA.
Sina AslanAdvance MRI, LLC, Frisco, TX 75034, USA.
Jeffrey S SpenceCenter for BrainHealth, The University of Texas at Dallas, Dallas, TX 75235, USA.
John J HartCenter for BrainHealth, The University of Texas at Dallas, Dallas, TX 75235, USA.
Elizabeth K BartzCenter for BrainHealth, The University of Texas at Dallas, Dallas, TX 75235, USA.
Nyaz DidehbaniCenter for BrainHealth, The University of Texas at Dallas, Dallas, TX 75235, USA.
Molly W KeeblerCenter for BrainHealth, The University of Texas at Dallas, Dallas, TX 75235, USA.
Claire M GardnerCenter for BrainHealth, The University of Texas at Dallas, Dallas, TX 75235, USA.
Jeremy F StrainCenter for BrainHealth, The University of Texas at Dallas, Dallas, TX 75235, USA.
Laura F DeFinaThe Cooper Institute, Dallas, TX 75230, USA and.
Hanzhang LuUniversity of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
The University of Texas at Dallas · USAdvance (Japan) · JPCooper Institute · USThe University of Texas Southwestern Medical Center · US

Funding

Mild Cognitive Impairment: Cerebrovascular Dysfunction and Exercise TrainingR01AG033106 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG, ZHANG, RONG · 2009 to 2012
$3.1M
Modulation of brain activity by control of the inspired airR01NS067015 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG · 2010 to 2013
$1.5M
Brain & Cognitive Changes after Reasoning or Physical Training in Cognitively NorRC1AG035954 · NIA · UNIVERSITY OF TEXAS DALLAS · PI CHAPMAN, SANDRA BOND · 2009 to 2010
$1.0M
NIA NIH HHS R01-AG033106NIA NIH HHS RC1-AG035954NINDS NIH HHS R01-NS067015
6 · The paper itself

Abstract

Complex mental activity induces improvements in cognition, brain function, and structure in animals and young adults. It is not clear to what extent the aging brain is capable of such plasticity. This study expands previous evidence of generalized cognitive gains after mental training in healthy seniors. Using 3 MRI-based measurements, that is, arterial spin labeling MRI, functional connectivity, and diffusion tensor imaging, we examined brain changes across 3 time points pre, mid, and post training (12 weeks) in a randomized sample (n = 37) who received cognitive training versus a control group. We found significant training-related brain state changes at rest; specifically, 1) increases in global and regional cerebral blood flow (CBF), particularly in the default mode network and the central executive network, 2) greater connectivity in these same networks, and 3) increased white matter integrity in the left uncinate demonstrated by an increase in fractional anisotropy. Improvements in cognition were identified along with significant CBF correlates of the cognitive gains. We propose that cognitive training enhances resting-state neural activity and connectivity, increasing the blood supply to these regions via neurovascular coupling. These convergent results provide preliminary evidence that neural plasticity can be harnessed to mitigate brain losses with cognitive training in seniors.

Indexed as

AgedAgingBrainBrain MappingCerebrovascular CirculationCognitionDiffusion Tensor ImagingFemaleHumansLearningMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysNeuronal PlasticityNeuropsychological Testsagingbrain plasticityCBFcognitive trainingMRI

Identifiers

PMID23985135
PMCPMC4351428
OpenAlexW2122134216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.