ArticleBioMed research international2013
Relationship between vitamin D receptor gene polymorphisms and migraine without aura in an Iranian population.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Vitamin D in migraine headache: a comprehensive review on literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Pooled it
- No evidence for an association of vitamin D deficiency and migraine: a systematic review of the literature.BioMed research international · 2014Pooled it
- Effect of vitamin D therapy in addition to amitriptyline on migraine attacks in pediatric patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Trial
- Unraveling the link: exploring what risk factor for sleep disorders among paediatric migraine.BMC neurology · 2025Article
- Exploring the Potential Consortium of Migraine and Periodontitis.International journal of dentistry · 2024Review
- Vitamin D receptor and binding protein genes variants in patients with migraine.Annals of clinical and translational neurology · 2023Article
- Genetic Variability in Vitamin D Receptor and Migraine Susceptibility: A Southeastern European Case-Control Study.Neurology international · 2023Article
- Relationship Between Vitamin D Receptor Gene BsmI Polymorphism and Fibromyalgia Syndrome.Cureus · 2022Article
- Vitamin D Receptor and Binding Protein Gene Variants in Patients with Essential Tremor.Molecular neurobiology · 2022Article
- VDR Gene Polymorphisms and Cluster Headache Susceptibility: Case-Control Study in a Southeastern European Caucasian Population.Journal of molecular neuroscience : MN · 2022Article
- Review
- Efficacy of Topiramate Alone and Topiramate Plus Vitamin D3 in the Prophylaxis of Pediatric Migraine: A Randomized Clinical Trial.Iranian journal of child neurology · 2020Article
- The potential role of serum vitamin D level in migraine headache: a case-control study.Journal of pain research · 2019Article
- Vitamin D deficiency in patients with cluster headache: a preliminary study.The journal of headache and pain · 2018Article
- Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men.Scientific reports · 2017Article
- Vitamin D status in migraine patients: a case-control study.BioMed research international · 2014Article
- Is Vitamin D Deficiency Implicated in Autonomic Dysfunction?Journal of pediatric neurosciencesReview
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammation has a key role in migraine pathophysiology. Vitamin D is an effective anti-inflammatory agent. The aim of this study was to investigate the association between migraine and two vitamin D receptor (VDR) polymorphisms (TaqI and FokI) and also the relationship between VDR polymorphisms and headache severity.
methodsIn this case-control study we assessed 103 patients with newly diagnosed migraine without aura and 100 healthy subjects. Patients filled headache impact test-6 (HIT-6) as a tool to assess headache severity.
resultsGenotype frequencies of VDR were significantly different between control and migraine patients. Heterozygote genotypes (Ff and Tt) were statistically more frequent in the migraine patients than the control subjects both for TaqI gene (P = 0.018; OR = 1.81, 95% CI = 1.03-3.18) and FokI gene polymorphisms (P = 0.001; OR = 2.91, 95% CI = 1.47-5.77). Also f and t alleles were more frequent in the migraine patients. Total HIT-6 score was significantly different between FokI heterozygote and homozygote patients (60.32 ± 1.87 versus 49.87 ± 2.69, resp., P = 0.004).
conclusionsIn conclusion our results showed that TaqI and FokI gene polymorphisms are associated with migraine without aura in Iranians patients. Also headache severity in FokI heterozygote patients was significantly greater than in the homozygote patients.
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