ArticleTherapeutic advances in psychopharmacology2011
Bipolar depression: clinically missed, pharmacologically mismanaged.
Article in Therapeutic advances in psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of the Interval between the Onset and Management of Bipolar Disorder.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Pooled it
- Soilless biofortification, bioaccessibility, and bioavailability: Signposts on the path to personalized nutrition.Frontiers in nutrition · 2022Review
- Affective lability as a prospective predictor of subsequent bipolar disorder diagnosis: a systematic review.International journal of bipolar disorders · 2021Review
- The Proposition for Bipolar Depression Forecasting Based on Wearable Data Collection.Frontiers in physiology · 2021Review
- Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant.Therapeutic advances in psychopharmacology · 2016Review
- The borderline of bipolar: opinions of patients and lessons for clinicians on the diagnostic conflict.BJPsych bulletin · 2015Article
- Characteristics of bipolar disorder patients treated with immediate- and extended-release quetiapine in a real clinical setting: a longitudinal, cohort study of 1761 patients.Therapeutic advances in psychopharmacology · 2015Article
- Ketamine as the prototype glutamatergic antidepressant: pharmacodynamic actions, and a systematic review and meta-analysis of efficacy.Therapeutic advances in psychopharmacology · 2014Review
- Lithium: the pharmacodynamic actions of the amazing ion.Therapeutic advances in psychopharmacology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bipolar affective disorders are common and frequently debilitating mental illnesses. Diagnostic criteria mean they are defined by the presence of pathological mood elevation, but research shows greater disease burden is inflicted by depressive phases (bipolar depression) both in terms of duration and impact of symptoms. Despite this there is consistent evidence for the underdiagnosis of bipolar depression and its misdiagnosis as a unipolar disorder, with significant subsequent impact on medication management. There is currently less robust evidence for the appropriate pharmacological approach in such individuals than in unipolar depression, and fewer guidelines for clinicians. Despite this there is clear and growing evidence that 'treatment as usual' of depressive symptomatology is ineffective at best, harmful at worst, and that there is little role for the use of antidepressants. Both mood stabilizers and antipsychotics demonstrate efficacy, and whilst there are emerging data on intraclass differences, more research is needed, particularly concerning bipolar II disorder. Present treatment strategies are limited by insufficient large randomized control trials, an inadequate understanding of the neuropathology of bipolar illnesses and a lack of tailored medications. Better clinical training, understanding and recognition of this common condition are essential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.