ArticleThe Neurohospitalist2011
Safety of thrombolysis in acute ischemic stroke: a review of complications, risk factors, and newer technologies.
Article in The Neurohospitalist, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
107 citing papers in PubMed, 4 syntheses or guidelines pooled it, 228 citations in OpenAlex.
- Endovascular thrombectomy plus intravenous thrombolysis versus endovascular thrombectomy alone for large ischemic stroke.Acta neurologica Belgica · 2026Pooled it
- Endovascular thrombectomy for acute stroke in anticoagulated patients: systematic review and Meta-Analysis.Journal of thrombosis and thrombolysis · 2026Pooled it
- The efficacy and safety of tenecteplase versus alteplase for acute ischemic stroke: an updated systematic review, pairwise, and network meta-analysis of randomized controlled trials.Journal of thrombosis and thrombolysis · 2023Pooled it
- Mechanical Thrombectomy With and Without Intravenous Tissue Plasminogen Activator for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis Using Nested Knowledge.Frontiers in neurology · 2021Pooled it
- Thrombolysis implementation intervention and clinical outcome: a secondary analysis of a cluster randomized trial.BMC cardiovascular disorders · 2020Trial
- The efficacy and safety of low-molecular-weight heparin and unfractionated heparin in the treatment of cerebral venous sinus thrombosis.Neurosciences (Riyadh, Saudi Arabia) · 2015Trial
- Clinical profiles of MRI-negative ischemia and stroke mimics after thrombolysis: insights into diagnostic uncertainty in acute ischemic stroke care.Journal of neurology · 2026Article
- Ultrasound-Induced Cavitation of Immunoliposomes for Rapid Drug Release, Deep Thrombus Penetration, and Enhanced Thrombolysis.ACS omega · 2026Article
- Tenecteplase versus alteplase for acute ischemic stroke.The Cochrane database of systematic reviews · 2026Article
- Predicting stroke-associated infection in acute ischemic stroke patients treated by thrombolysis.Frontiers in cellular neuroscience · 2026Article
- Cardiovascular Risk Factors Involved in Hemorrhagic Transformation After Intravenous Thrombolytic Therapy in Patients with Acute Ischemic Stroke.International journal of molecular sciences · 2025Review
- Intravenous Thrombolysis in Cervical Artery Dissection-Related Stroke: A Nationwide Study.Journal of the American Heart Association · 2025Article
- Dual role of vascular endothelial growth factor-C in post-stroke recovery.The Journal of experimental medicine · 2025Article
- Management of acute ischemic stroke in the emergency department: optimizing the brain.International journal of emergency medicine · 2025Review
- The role of ASPECTS score, atrial fibrillation, and revascularization therapy in predicting hemorrhagic transformation of ischemic stroke: results from a prospective cohort study.Frontiers in neurology · 2025Article
- Transfer of Mitochondria from Healthy Stem Cells to Injured Cells in Stroke with Retinal Impairments.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Molecular Mechanism of MLC 901 in Acute Ischemic Stroke: A Review.Stroke research and treatment · 2025Review
- Large right middle cerebral artery stroke with hemorrhagic transformation.International journal of emergency medicine · 2024Article
- Life-Threatening tPA-Associated Angioedema: A Rare Case Report and Critical Review.The American journal of case reports · 2024Review
- Ultrasound-responsive theranostic platform for the timely monitoring and efficient thrombolysis in thrombi of tPA resistance.Nature communications · 2024Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intravenous recombinant tissue plasminogen activator (r-tPA) was approved for use in acute ischemic stroke in the United States in 1996. Approximately 2% to 5% of patients with acute ischemic stroke receive r-tPA. Complications related to intravenous r-tPA include symptomatic intracranial hemorrhage, major systemic hemorrhage, and angioedema in approximately 6%, 2%, and 5% of patients, respectively. Risk factors for symptomatic hemorrhage include age, male gender, obesity, increased stroke severity, diabetes, hyperglycemia, uncontrolled hypertension, combination antiplatelet use, large areas of early ischemic change, atrial fibrillation, congestive heart failure, and leukoariosis. A risk factor for angioedema is the use of angiotensin-converting enzyme inhibitor. Risk assessment scores, novel imaging strategies, and telemedicine may offer methods of optimizing the risk-benefit ratio.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.